摘要
目的探讨HSP70在手术损伤后对肝脏可能的保护作用,以及与其他应激反应的关系。方法 400只SD大鼠通过建立不同程度肝切模型随机分为对照组、轻度损伤组、中度损伤组和重度损伤组。每组100只,分别在术前及术后2、12、24、48h进行分批处理(每时间点均20只),采集血液标本,检测淋巴细胞HSP70表达、血皮质醇及ALT和TB的水平,并分析相关关系。结果淋巴细胞HSP70表达与肝功能指标存在一定关联性,淋巴细胞HSP70表达与血皮质醇水平的关联性较强。结论 HSP70在机体手术损伤所致应激反应中有可能抑制了肝功能恶化,对机体器官有一定保护作用,并且HSP70与应激中有重要作用的糖皮质激素(GC)存在一定关系,有一定协同作用。
Objective To explore the protective effect of HSP 70 in surgical trauma and the relationship between expression of HSP 70 and other stress response.Methods Four-hundred SD rats with different extents of hepatectomy were randomly divided into control group,mild trauma group,moderate trauma group and severe trauma group,100 rats in each group.Taking blood samples separately in each group at 12h before operation as well as 2h,12h,24h and 48h after operation.HSP 70 in lymphocytes,blood ALT,TB and cortisol were detected,and the relationships among them were analyzed.ResultsThe expression of HSP 70 was related to liver function and blood cortisol.ConclusionsHSP 70 plays an important role in inhibiting the deterioration of liver function,and there might be synergy between HSP 70 and Glucocorticoid.
出处
《中国癌症防治杂志》
CAS
2010年第2期81-84,共4页
CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
基金
广西自然科学基金资助项目(桂科自0728123)
