摘要
胰岛移植是一种治疗糖尿病的有效方法，却因供体来源缺乏和免疫排斥等问题难以广泛应用。在正常机体中，胰岛β细胞的冉生与凋亡处于动态平衡中。胰腺损伤等条件能刺激内源性β细胞再生以满足机体对胰岛素的需求。成体中内源性β细胞再生的来源主要包括胰腺干／祖细胞分化、β细胞自身分裂增殖和其他类型细胞转分化3种途径。一些小分子药物及非β细胞的移植能够有效刺激内源性β细胞的再生，有望成为治疗糖尿病的新方法；
Transplantation of islets offers an attractive strategy for the treatment of diabetes,but its wide application has been limited by donor shortage and immunological rejection after transplantation. During normal pancreatic tissue turnover,the renewal and apoptosis of β cells are in homeostasis. After the destruction of existing β cells through physical or chemical injuries, β cells could be regenerated from pancreatic stem/progenitor cells differentiation,self-duplication of preexisting β cells or transdifferentiation from other cell types. Both small-molecule medicines and transplantation of non-β cells can stimulate the endogenous β cell regeneration,they would he new methods for treatment of diabetes.
出处
《国际内分泌代谢杂志》
2010年第B04期39-42,共4页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（30670304）
关键词
糖尿病
Β细胞
再生
胰腺干/祖细胞
Diabetes mellitus
β Cell regeneration
Pancreatic stem/progenitor cells
