摘要
目的观察利培酮治疗前后精神分裂症患者记忆功能的变化及COMT基因Val158Met多态性与记忆功能的关系。方法采用聚合酶链反应(PCR)和限制性片断长度多态性(RFLP)方法对83例精神分裂症患者COMT基因多态性进行检测,并选用中国版韦氏记忆测验(WMS),对83例精神分裂症患者单用利培酮治疗8周,分别在治疗前和治疗后进行测评。结果 COMT各基因组之间WMS比较差异无显著性差异(P>0.05)。83例精神分裂症患者经利培酮治疗8周后,除了联想测验分治疗前后比较无统计学意义外,其余记忆商(MQ)、经历、定向等测验分均有显著性差异(P<0.05)。结论 COMT基因Val158/108Met多态性对精神分裂症患者记忆功能的影响可能不起重要作用,但利培能明显提高精神分裂症患者记忆功能。
OBJECTIVE To investigate change of Schizophrenia patients in memery function and the relation-ship between COMT Val108/158Met polymorphism and memery function after taking Resperidone.METHDOS Polymerase Chain Reaction（PCR） and Restriction Fragment Length Polymorphism（RFLP） were used to detect COMT gene polymorphism of 83 patients with Schizophrenia.Using the Chinese version of Wechsler Memery Scale（WMS） to evaluate 83 cases of Schizophrenia treated with Risperidone alone in 8 weeks before and after treatment.RESULTS The difference of WMS evaluation between the COMT gene in groups was not significant（P0.05）.After 83 patients with Schizophrenia treated with Risperidone for 8 weeks,Except for Sub-association test before and after treatment showed no statistical significance,the remaining memery quotient（MQ）,experience,orientation and other test scores were significantly different（P0.05）.CONCLUSIONS COMT gene Val158/108Met polymorphism may not play an important role in memery function of patients with Schizophrenia,but Risperidone may improve memery function in patients with Schizophrenia.
出处
《海峡药学》
2010年第6期105-107,共3页
Strait Pharmaceutical Journal
基金
宁波市医学科技计划项目(NO.2004050)
