摘要
目的:探讨HIF-1α和VEGF在宫颈上皮内瘤变及宫颈癌组织中表达及临床意义。方法:应用免疫组化方法检测119例宫颈病变(70例CIN及49例宫颈癌)及30例正常宫颈组织中HIF-1α和VEGF的表达。结果:CIN、早期宫颈癌组HIF-1α和VEGF阳性率明显高于其他组(P<0.05),且二者表达有相关性(P<0.05)。HIF-1α表达率与临床分期及病理分级有关(P<0.05)。结论:HIF-1α和VEGF在宫颈上皮内瘤变和早期宫颈癌组织中呈高表达状态,提示检测HIF-1α和VEGF对早期诊断宫颈癌有重要意义,选择性HIF-1α抑制剂为宫颈癌的治疗提供了新靶点。
Objective：To explore the expression levels and clinical significance of hypoxia-inducible factor 1α（HIF-1α） and vascular endothelial growth factor（VEGF） in cervical intraepithelial neoplasia（CIN） and cervical carcinoma.Methods：The expression levels of HIF-1α and VEGF in 119 cases with cervical lesions（70 cases with CIN and 49 cases with cervical carcinoma） and 30 cases with normal cervical tissues were detected by immunohistochemical method.Results：The positive rates of HIF-1α and VEGF in CIN group and early cervical carcinoma group were significantly higher than those in other groups（P〈0.05）,there was a correlation between HIF-1α expression and VEGF expression（P〈0.05）,the expression rate of HIF-1α was related to clinical stage and pathological grade（P〈0.05）.Conclusion：High expression levels of HIF-1α and VEGF in CIN and cervical carcinoma indicate that detection of HIF-1α and VEGF plays an important role in early diagnosis of cervical carcinoma,specific HIF-1α inhibitor might provide a new target for therapy of cervical carcinoma.
出处
《中国妇幼保健》
CAS
北大核心
2010年第18期2557-2559,共3页
Maternal and Child Health Care of China
关键词
HIF-1Α
VEGF
宫颈上皮内瘤变
宫颈癌
Hypoxia-inducible factor 1α
Vascular endothelial growth factor
Cervical intraepithelial neoplasia
Cervical carcinoma
