摘要
目的:观察激素替代疗法(HRT)对围绝经期妇女颈动脉及大脑中动脉的影响。方法:选择规律HRT治疗的围绝经期妇女30例及未经任何激素治疗的围绝经期妇女20例作为对照组。在治疗前及治疗1年后,彩色多普勒检测HRT组及对照组颈动脉及大脑中动脉,检测指标包括颈动脉内径、内中膜厚度(IMT),动脉粥样硬化斑块,颈动脉及大脑中动脉收缩期峰值血流速度(PSV)、搏动指数(PI)、阻力指数(RI)、峰值血流速度与最小血流速度之比(S/D)。同时检测血脂水平。结果:HRT组治疗前与对照组颈动脉及大脑中动脉超声检查差异无统计学意义(P>0.05)。1年后复查,颈动脉平均IMT及动脉硬化斑块发生率HRT组明显低于对照组(P<0.01);颈总动脉、颈内动脉PSV、RI、PI、S/D及大脑中动脉PSV HRT组与对照组比较差异无统计学意义(P>0.05);大脑中动脉RI、PI、S/D HRT组低于对照组(P<0.01)。结论:HRT对围绝经期妇女脑血管有保护作用。
Objective：To observe the effect of hormone replacement therapy（HRT） on carotid artery and middle cerebral artery in perimenopausal women.Methods：30 perimenopausal women receiving regular HRT and 20 perimenopausal women without any hormone therapy were selected as HRT group and control group,respectively,before treatment and one year after treatment,carotid artery and middle cerebral artery in HRT group and control group were detected,detection indexes included inner diameter of carotid artery,thicknesses of intima and media（IMT）,atherosclerotic plaque,peak systolic velocity（PSV） of carotid artery and middle cerebral artery,pulsatility index（PI）,resistance index（RI）,S/D.The level of blood lipid was detected.Results：There was no significant difference in detection indexes of carotid artery and middle cerebral artery between HRT group before treatment and control group（P〉0.05）,one year later,the average IMT and incidence of atherosclerotic plaque in HRT group were significantly lower than those in control group（P〈0.01）;there was no significant difference in PSV,RI,PI and S/D of common carotid artery and internal carotid artery and PSV of middle cerebral artery between HRT group and control group（P〉0.05）;RI,PI and S/D of middle cerebral artery in HRT group were significantly lower than those in control group（P〈0.01）.Conclusion：HRT has an protective effect for cerebral vessels of perimenopausal women.
出处
《中国妇幼保健》
CAS
北大核心
2010年第18期2539-2541,共3页
Maternal and Child Health Care of China
关键词
激素替代疗法
围绝经期
颈动脉
大脑中动脉
Hormone replacement therapy
Perimenopause
Carotid artery
Middle cerebral artery
