期刊文献+

HIV早期感染诊断及其对预防的重要意义 被引量:7

Detection of early HIV infection and its implications on the prevention
原文传递
导出
摘要 HIV抗体检测技术是发现HIV感染者的常规实验室诊断技术。然而,抗体检测不能发现HIV感染至抗体阳转这一早期感染阶段,此阶段感染者体内会出现高病毒血症和高抗原血症,具有极强的传染性。因此,开展HIV早期感染检测具有极其重要的临床意义。现就HIV早期感染检测技术进展以及该技术在血液安全,HIV感染早期干预、治疗以及估计发病率中的应用情况作一综述。 HIV antibody test is routinely utilized in lab for dectection of HIV infection. However,it unable to detect HIV infection at early stage of infection before the seroconversion. Furthermore ,HIV can conduct a high level viremia and antigenemia in infected person's body and is extremely contagious in this period. Therefore,developing the diagnosis of recent infection has great clinical implications. Our goal is to review the progress on technique to detect HIV early infection and its application on blood safey,intervention of HIV early infection,AIDS treatment and testing for HIV incidence.
出处 《中国热带医学》 CAS 2010年第8期913-916,共4页 China Tropical Medicine
基金 国家"十一五"重大专项-艾滋病防治项目(2008ZX10001-003)
关键词 HIV 早期感染 P24抗原 集合检测 HIV Early infection P24 Antigen Pooling test
  • 相关文献

参考文献35

  • 1AIDS Epidemic Update 2009 . http'J/data.unaids.org/pub/Report/2009/ JC 1700 Epi_Update_2009_en.pdf[ OL ]. 被引量:1
  • 2卫生部介绍中国艾滋病疫情现状.http://www.chinaids.org.cn/n16/n1193,n4073,302767.html.[OL]. 被引量:3
  • 3Quinn TC,Brookmeyer R,Kline R,et al . Feasibility of pooling sera for HIV-1 viral RNA to diagnose acute primary HIV-1 infection and estimate HIV incidence[J] . AIDS,2000,14:2751-2757. 被引量:1
  • 4Ledergerber B,Flepp M,Bonl J,et al . Human immunodefieiency virus type 1 p24 concentration measured by boosted ELISA of heat- denatured plasma correlates with decline in CD4 cells,progression to AIDS,and survival: comparison with viral RNA measurement [J] . J Infect Dis,2000,181 : 1280-1288. 被引量:1
  • 5dos Ramos Farias MS,Garcia MN,Dilernia D,et al . Centrifugation improves the detection of HW-1 p24 antigen in plasma from children born to mothers infected with HIV-1 [J] . J Virol Methods, 2009,158 : 6-10. 被引量:1
  • 6Schupbach J,Tomasik Z,Knuchel M,et al . Optimized virus disruption improves detection of HIV-1 p24 in particles and uncovers a p24 reactivity in patients with undetectable HIV-1 RNA under long-term HAART[ J ] . J Med Virol, 2006,78:1003-1010. 被引量:1
  • 7Sutthent R,Gaudart N,Chokpaibulkit K,et al. p24 Antigen detection assay modified with a booster step for diagnosis and monitoring of human immunodefieiency virus type 1 infection [J] . J Clin Microbiol, 2003,41 : 1016-1022. 被引量:1
  • 8Tang S,Zhao J,Storhoff JJ, et al. Nanoparticle -Based biobarcode amplification assay (BCA)for sensitive and early detection of human immunodeficiency type 1 capsid(p24)antigen[J] . J Acquir Immune Defic Syndr, 2007,46: 231-237. 被引量:1
  • 9吴忠华,罗鹏,吕沁风.HIV实验室检测及其研究进展[J].中国国境卫生检疫杂志,2009,32(4):285-292. 被引量:15
  • 10全国艾滋病检测技术规范[S].(修订版),2009. 被引量:1

二级参考文献15

  • 1郑晓丽.HIV检测研究进展与发展趋势[J].现代检验医学杂志,2004,19(6):64-67. 被引量:13
  • 2张涛,谢莹,陈朝银.HIV检测方法研究进展[J].吉林化工学院学报,2007,24(3):43-47. 被引量:3
  • 3Quinn TC,Brookmeyer R, Kline R, et al. Feasibility of pooling sera for HIV-1 viral RNA to diagnose acute primary HIV-1 infection and estimate HIV incidence[J]. AIDS, 2000,14:2751 - 2757. 被引量:1
  • 4Pilcher CD, Mcpherson JT, Leone PA, et al. Real-time, universal screening for acute HIV infection in a routine HIV counseling and testing population[J] .JAMA, 2002,288:216-221. 被引量:1
  • 5Palla P, Vatteroni ML, Vacri L, et al. HIV-1 NAT minipool during the pre-seroconversion window period: detection of a repeat blood donor[J]. Vox Sang,2006,90(1) :59 - 62. 被引量:1
  • 6Daar ES,Little S, Pitt J, et al. Diagnosis of primary HIV-1 infection [J]. Annals of internal medicine 2001,134:25 - 29. 被引量:1
  • 7Kilmarx PH, Limpakarnjanarat K, Mastro TD, et al. HIV-1 seroconversion in a prospective study of female sex workers in northern Thailand: Continued high incidence among brothel-based women [ J ]. AIDS, 1998,12:1889 - 1898. 被引量:1
  • 8Nopkesorn T, Mock PA, Mastro TD, et al. HIV-1 subtype E incidence and sexually transmitted diseases in a cohort of military conscripts in northern Thailand [J]. J Acquir Immune Defic Syndr Hum Retroviral, 1998,18 : 372 - 379. 被引量:1
  • 9Vanichseni S,Kitayaporn D,Mastro TD,et al. Continued high HIV-1 incidence in a vaccine trial preparatory cohort of injection drug users in Bangkok,Thailand [J]. AIDS,2001,15 : 397 - 405. 被引量:1
  • 10Wilkinson D, Abdool Karim SS, Williams B, et al. High incidence of HIV-1 infection among young women in rural South Africa:developing a cohort for intervention trials [J]. J Acquir Immune Defic Syndr, 2000,3:405 - 409. 被引量:1

共引文献37

同被引文献48

  • 1秦国天.用非特异性反应标本选择抗-HIV试剂[J].中国输血杂志,2005,18(3):229-230. 被引量:2
  • 2许文燕,邱茂锋,佐合拉.吐尔地,邢文革,蒋岩.第四代HIV抗原抗体酶联检测试剂缩短HIV检测窗口期的研究[J].中华检验医学杂志,2007,30(3):284-287. 被引量:63
  • 3吴瑞英.不同方法对两例早期HIV感染者血清抗体追踪检测研究[J].中国艾滋病性病,2007,13(5):462-463. 被引量:9
  • 4Wawer M J, Serwadda D, Li X, et al. HIV transmission per coital act, by stage of HIV index partner,in discordant couples: Rakai, U- ganda. 10th Conference on Retroviuses and Opportunistic. Infec- tions, Boston. USA ,2003. 被引量:1
  • 5王临虹.预防艾滋病母婴传播技术指导手册[M].3版.北京:人民卫生出版社,2011. 被引量:5
  • 6Senturk H,Tahan V,Canbakan B,et al.Chronic hepati-tis C responds poorly to combination therapy in chronichepatis B carriers.Neth J Med,2008,66(5):191-195. 被引量:1
  • 7Chen CH,Chen YY,Chen GH,et al.Hepatitis B virus transmission and hepatocarcinogenesis:a 9 year retrospective cohort of 13676 relatives with hepatocellular carcinoma.J He patol,2004,40(4):653-659. 被引量:1
  • 8Wawer MJ,Serwadda D,Li X,et al.HIV transmission per coital act,by stage of HIV index partner,in discordant couples:Rakai,Uganda.10th Conference on Retroviuses and Opportunistic.Infections,Boston.USA,2003. 被引量:1
  • 9Carrilho FJ,Ono Nita SK,Cardoso RA,et al.Aprospective study of hepatitis B virus markers in patients with chronic HBV infection from Brazilian families of Western and Asian origin.Braz J Med Biol Res,2005,38(9):1399-1408. 被引量:1
  • 10Lee S,Kim YS,Jo M,et al.Chip-based detection of hepatitis C virus using RNA aptamers that specifically bind to HCV core antigen.Biochem Biophys Res Commun,2007,358(1):47-52. 被引量:1

引证文献7

二级引证文献45

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部