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卡介苗多糖核酸辅助治疗白癜风的疗效及对T淋巴细胞亚群的影响 被引量:2

BCG PSN adjuvant treatment of vitiligo and on t-lymphocyte subpopulation
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摘要 目的观察卡介苗多糖核酸辅助治疗白癜风的疗效及对外周血T淋巴细胞亚群的影响。方法90例白癜风患者随机分为实验组(50例)和常规治疗对照组(40例),比较卡介苗多糖核酸辅助治疗后T淋巴细胞亚群比例变化。结果治疗后实验组总有效率明显高于常规治疗对照组(54%VS 27.5%,P<0.05);治疗前白癜风患者外周血CD3、CD4及CD4/CD8较正常低(P<0.05),治疗后实验组CD3、CD4及CD4/CD8均升高,与治疗前比较有显著性意义(P<0.05),而常规治疗组治疗前后比较无显著性差异(P>0.05)。结论白癜风患者存在T细胞免疫功能异常,采用卡介苗多糖核酸辅助治疗能提高患者的CD4+T细胞亚群比例,临床可获得较好疗效。 Objective To observe BCG PSN assisted Vitiligo and peripheral T lymphocyte subsets.Methods Of 90 cases of Vitiligo were randomly divided into experimental groups(50 cases),and the General treatment of the control group(40 patients),and compared the BCG vaccine adjuvant therapy after PSN T lymphocyte subsets.Results Experimental group total effective 54%,General treatment control group is 27.5%(P0.05).Before the treatment,patients with Vitiligo CD3,CD4 and CD4/CD8 below normal(P0.05).After treatment,the CD4 comprehensive set of CD3,and CD4/CD8 were significantly elevated,and there were no significant changes for the control group(P0.05).Conclusion Vitiligo have t-cell immune dysfunction.Using BCG PSN adjuvant therapy can improve the patient's CD4+T cell subsets with better clinical outcomes.
出处 《济宁医学院学报》 2010年第3期167-169,共3页 Journal of Jining Medical University
关键词 卡介苗多糖核酸 白癜风 T淋巴细胞亚群 BCG-PSN Vitiligo T-lymphocyte subsets
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