摘要
目的观察体外循环(ECC)下行心脏瓣膜术中应用门冬氨酸钾镁(PMA)对肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白T(cTnT)的影响。方法 40例择期心脏瓣膜置换患者随机分成PMA组与对照(C)组,每组20例。PMA组心肌保护液维持Mg2+浓度为4mmol/L;C组心肌保护液中不含Mg2+。监测术前、术毕、术后6、24、72hCK-MB和cTnT值。结果两组术后CK-MB和cTnT均比术前明显升高(P<0.05)。PMA组术毕、术后6和24h的CK-MB明显低于C组[(42.1±8.3)IU/Lvs.(77.4±12.5)IU/L、(30.6±5.8)IU/Lvs.(53.2±9.5)IU/L、(16.4±6.3)IU/Lvs.(37.4±10.8)IU/L](P<0.05);PMA组cTnT也明显低于C组[(0.31±0.08)μg/Lvs.(0.93±0.25)μg/L、(0.55±0.10)μg/Lvs.(1.14±0.21)μg/L、(0.68±0.12)μg/Lvs.(1.37±0.36)μg/L](P<0.05)。结论门冬氨酸钾镁在心脏瓣膜病体外循环手术中有心肌保护作用。
Objective To investigate the effects of potassium magnesium aspartate（PMA）on creatine kinase-MB（CK-MB）and calcitonin-T（cTnT）during heart valve replacement under extracorporeal circulation（ECC）.Methods Forty patients undergoing heart valve replacement were randomly divided into two groups with 20 cases each.The magnesium 4 mmol/L in PMA cardioplegia solution was added in group PMA,which was not in group C as the control.Plasma CK-MB and cTnT were detected before operation,at the end of surgery,6,24 and 72h after operation.ResultsCompared to before,plasma CK-MB and cTnT were significantly increased after operation（P0.05）.Plasma concentrations of CK-MB at the end of surgery,6 and 24h after operation were significantly lower in group PMA than those in group C[（42.1±8.3）IU/L vs.（77.4±12.5）IU/L,（30.6±5.8）IU/L vs.（53.2±9.5）IU/L and（16.4±6.3）IU/L vs.（37.4±10.8）IU/L]（P0.05）.So did cTnT [（0.31±0.08）μg/L vs.（0.93±0.25）μg/L,（0.55±0.10）μg/L vs.（1.14±0.21）μg/L and（0.68±0.12）μg/L vs.（1.37±0.36）μg/L]（P0.05）.Conclusion The magnesium 4mmol/L added into cardioplegia solution has myocardial protective effect in the patients undergoing heart valve replacement under ECC.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第11期1259-1260,共2页
Jiangsu Medical Journal
关键词
门冬氨酸钾镁
心肌保护
体外循环
Potassium magnesium aspartate
Myocardial protection
Extracorporeal circulation
