摘要
目的:应用CT灌注技术观察肝泡球蚴病(HAE)的影像特征,并分析病灶边缘区域CT灌注参数与组织病理学指标的关系,探讨CT灌注在评价HAE边缘区域血流状态的应用价值。方法:28例HAE患者行肝脏CT灌注检查,获得病灶中心、病灶边缘区域及周围肝脏组织的各项灌注参数,包括血流量(BF)、血容量(BV)、平均通过时间(MTT)、毛细血管表面通透性(PS)、肝动脉灌流分数(HAF)、肝动脉灌流量(HAP)及门静脉灌流量(PVP);其中17例患者手术治疗,观察新鲜手术标本后取病灶边缘区域HE染色和免疫组化测定微血管密度(MVD),分析CT灌注各项参数与MVD的相关性。结果:28例中选取独立HAE病灶31个,测得病灶中心、病灶边缘区域及周围肝脏组织的各项灌注参数的均值之间的差异均有统计学意义(P<0.05),其中病灶边缘区域组与周围肝脏组织组的BF、MTT、PS、HAP、PVP参数间差异有统计学意义(P<0.05),BV、HAF参数间差异无统计学意义(P>0.05);17例术后病灶边缘区域CT灌注参数BF、HAF、HAP与MVD呈正相关(P<0.05)。结论:HAE病灶与周围肝组织间存在边缘浸润带,该区域血流灌注高于病灶内部及周围肝脏组织,CT灌注成像可以反映这一区域的血流状态及病灶的浸润范围,具有较高的临床应用价值。
Purpose：To observe the imaging features of CT perfusion in hepatic alveolar echinococcosis（HAE） and analyze the correlation between CT perfusion parameters of peripheral zone of HAE and microvessel density （MVD）,and to investigate the clinical value of CT perfusion technology in evaluating the hemodynamic changes of HAE.Methods：28 cases with HAE underwent GE 64-slice spiral CT perfusion. The perfusion parameters of the center,the peripheral zone and the surrounding liver tissue of lesion were measured through liver perfusion analysis software,which including blood flow （BF）,blood volume （BV）,mean transit time（MTT）,permeability surface area product（PS）,hepatic arterial fraction （HAF）,hepatic arterial perfusion （HAP）and portal vein perfusion （PVP）. Of the 28 cases with HAE,17 cases underwent operations.The lesions were stained with routine HE. MVD of the peripheral zone was examined by immunohistochemical techniques.The correlation between CT perfusion parameters and MVD were analyzed.Results：There was statistically significant difference in BF,BV,MTT,PS,HAF,HAP and PVP among the groups of the center,the peripheral zone and the around liver tissue of 28 patients with 31 lesions.The difference of BF,MTT,PS,HAF,HAP and PVP between the groups of the peripheral zone of lesion and the surrounding liver tissue of lesion were statistically significant （P 0.05）. However,the differences of BV and HAF between the two groups were not statistically significant（P 0. 05）. Positive relations were shown between the BF,HAF,HAP of peripheral zone of lesion and MVD. Conclusion：The blood supply of peripheral zone of HAE is much more than that in the center of the lesion and surrounding liver tissue. CT perfusion technique is of clinical significance in analyzing the change of the blood flow of the peripheral zone and invasive extent of HAE.
出处
《中国医学计算机成像杂志》
CSCD
北大核心
2010年第3期215-220,共6页
Chinese Computed Medical Imaging
基金
国家自然科学基金(No .30960100)~~
