摘要
目的:探讨转化生长因子β1(TGF-β1)在非小细胞肺癌患者血清中的检测水平及临床意义。方法:采用ELISA酶免疫分析技术检测53例非小细胞肺癌、31例肺良性疾病、38例正常对照者血清TGF-β1的水平。结果:化疗前NSCLC组患者血清TGF-β1水平明显高于正常对照组及肺良性疾病组,差异显著(P<0.01),肺良性疾病组与正常对照组比较差异不明显(P>0.05),NSCLC肿瘤转移组血清TGF-β1水平明显高于无转移组(P<0.05),化疗前后NSCLC组差异显著(P<0.05)。结论:TGF-β1与NSCLC发病有关,血清TGF-β1水平可作为NSCLC患者辅助诊断和疾病观察重要肿瘤标志物之一。
Objective：To investigate the chang and clinicalmenning of serum TGF-β1 in non-small cell lung cancer（NSCLC）.Methods：The levels of serum TGF-β1 were determined by ELISA in 53 patients with NSCLC and 31 patients with benign lung diseases and 38 healthy volunteers.Results：The levels of serum TGF-β1 with NSCLC patients before chemotherapy were significantly higher than that of the patients with benign ones（P〈0.01） and the patients after chemotherapy（P〈0.05）,There was not a significant difference in the content of serum TGF-β1 of benign lung diseases and healthy volunteers,Metastatic disease was associated with higher TGF-β1 than localized diseased（P〈0.05）.Conclusion：Higher levels of serum TGF-β1 may be related to the pathogenesis and development of the disease,and serum TGF-β1 could be used as one of diagnostic and efficacy observation indicators in patients with NSCLC.
出处
《中国卫生检验杂志》
CAS
2010年第6期1456-1457,共2页
Chinese Journal of Health Laboratory Technology
关键词
非小细胞肺癌
TGF-Β1
酶联免疫吸附方法
Non-small cell lung cancer（NSCLC）
TGF-β1
Enzyme-linked immunoabsorbent assay（ELISA）
