摘要
目的对泰山地区283对有不良孕产史的夫妇进行细胞遗传学检查,探讨泰山地区染色体畸变与不良孕产的关系。方法取患者外周血淋巴细胞进行染色体制备,利用染色体G显带技术对染色体核型进行分析,并对结果进行统计学分析。结果 566例患者共检出染色体变异39例,男性28例,女性11例,检出率为6.89%。其中大Y 16例,在男性患者中检出率为5.65%;随体变异12例,检出率为2.12%;9ph+2例,检出率为0.35%;染色体易位4例,检出率为0.71%;除大Y外其它性染色体异常5例,检出率为0.88%。结论染色体异常是导致不良孕产的重要因素。
Objective： To explore the relationship between chromosomal abnormalities and habitual abortion, the cytogenetic check was done on 283 cases with the history of habitual abortion. Methods ： Human peripheral blood lymphocytes were prepared for chromosome preparation and chromosome G - banding analysis, then statistical analysis was used. Results ： 39 cases of chromosome polymorphism （the male was 28, the female was 11 ） were detected among 566 cases patients, and the detection rate was 6. 89%. As for big Y, the detection rate was 5.65% ; 12 cases were aberrant on satellite with the detection rate 2. 12% ; 2 cases were 9ph ＋ and the detection rate was 0. 35% ; The prosecution rate of translocation was 0. 71% with d cases; Other variation on sex chromosomal were 5 eases with a detection rate of 0. 88%. Conclusion： Chromosomal abnormalities was very important to habitual abortion.
出处
《中国优生与遗传杂志》
2010年第6期42-43,41,共3页
Chinese Journal of Birth Health & Heredity
关键词
泰山地区
不良孕产
染色体多态
Taishan region
Adverse pregnancy
Chromosome polymorphism
