摘要
目的观察奥曲肽联合奥美拉唑治疗门脉高压并上消化道出血术后再出血的疗效。方法将91例门脉高压症术后患者随机分为A组37例和B组54例。A组给予奥曲肽联合奥美拉唑治疗,B组单用奥美拉唑治疗。观察2组的止血效果。结果 A组24h止血显效率为81.08%高于B组的61.11%,差异有统计学意义(P<0.01);止血时间A组为(20.78±5.46)h短于B组的(27.14±5.95)h,差异有统计学意义(P<0.05);48h后再出血率A组为2.70%低于B组的14.82%,A组输血量为(1.68±0.56)U少于B组(2.89±0.53)U,差异均有统计学意义(P<0.05)。结论奥曲肽联合奥美拉唑治疗非曲张静脉上消化道出血有显著疗效,较单用奥美拉唑有止血速度快、输血量减少、早期再出血发生率低的特点。
Objective To observe the efficacy of octreotide combined with omeprazole in the portal hypertension patients with postoperative rehaemorrhagia in upper gastrointestinal bleeding.Methods 91 cases of the rehaemorrhagia of upper gastrointestinal bleeding were randomly divided into group A（37 cases）and group B（54 cases）.Group A received octreotide plus omeprazole,while group B was treated with omeprazole alone,observed the hemostatic effect between these two groups.Results The 24h markedly effective rate of group A was significantly higher than that of group B（81.08% vs 61.11%,P0.01）;The haemostasis time（h）of group A was shorter than that of group B（20.78±5.46 vs 27.14±5.95,P0.05）;The blood transfusion requirement（U）and the rebleeding rate after the first 48 hours of group A were less than that of group B（1.68±0.56 vs 2.89±0.53,2.70% vs 14.82%）,the differences were statistically significant（P0.05）.Conclusion The combination of octreotide and omeprazole infusion is more effective than omeprazole alone in non-variceal upper gastrointestinal hemorrhage,it can lead to speeder up haemostasis pacing,fewer blood transfusion requirements and prevent early rebleeding effectively.
出处
《临床合理用药杂志》
2010年第12期8-9,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
奥美拉唑
奥曲肽
门脉高压
上消化道出血
Omeprazole
Octreotidel
Portal hypertension
Upper gastrointestinal hemorrhage
