摘要
目的研究冠心病患者阿司匹林抵抗(Aspirin Resistance,AR)现象与血小板P-选择素(P-selec-tion,PS)表达相关性及其影响因素。方法冠心病患者50例,测定干预前PS水平,阿司匹林100mg1次/晚干预2周,测定血小板聚集率,筛选出AR及敏感(Aspirin Sensitive,AS)两组,测定干预后PS表达。结果 AR的发生率为18%,低密度脂蛋白水平和高血压是AR的独立危险因素。AR组患者服药后PS水平显著高于AS组。结论低密度脂蛋白水平和高血压是发生AR的独立危险因素。PS可作为检测AR的有效指标。
Objective To study the correlation between PS expression and aspirin resistance（AR）and its risk factors in coronary disease.Methods 50 patients took aspirin 100mg/d for two weeks,and platelet aggregation（PAG）was detected.According to PAG,patients were divided into two groups：aspirin-resistant（AR）and aspirin-sensitive（AS）.PS expression was detected before and after treatment.Results 18% patients showed AR.Blood LDL-C level and hypertension are independent factors of AR.The expression of PS was significantly higher in AR patients than in AS.Conclusion AR is more likely to occur in high blood LDL-C level and hypertension.PS expression is an effective standard in measuring AR.
出处
《实用心脑肺血管病杂志》
2010年第6期740-741,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
