摘要
目的:检测女性不明原因不孕、不育症血清瘦素(leptin)、AsAb、EmAb(均为IgG抗体)及其临床意义,为女性不明原因不孕不育症患者提供诊断和治疗依据。方法:临床选择32例女性不明原因不孕不育症患者应用放免法和ELISA进行血清leptin、AsAb、EmAb三项技术统计分析并与35名正常健康妇女作比较。结果:32例女性不明原因不孕不育症患者血清leptin水平均显著低于正常妇女组(P<0.01),而AsAb、EmAb两项阳性者占78.1%,EmAb阳性者占21.9%。结论:leptin水平低下和免疫因素为女性不明原因不孕不育症的主要原因。
Objective To study the clinical significance of determination of serum leptin,AsAb,and EmAb levels in infertile women.Methods Serum leptin（with RIA）and AsAb,EmAb（with ELISA）levels were detected in 32 infertile women and 35 controls.Results Serum leptin levels in infertile women were significantly lower than those in controls（P0.01）.Serum AsAb and EmAb were both positive in 25 of the 32 infertile women（78.1%）and EmAb（one of two Abs）was positive in the rest 7 women（21.9%）.These positive rates were also significantly higher than the respective ones in the controls（both P0.01）.Conclusion Lower serum leptin level with highly positive AsAb and EmAb might be the chief cause of infertility in women.
出处
《放射免疫学杂志》
CAS
2010年第3期267-269,共3页
Journal of Radioimmanology
关键词
女性不孕不育
瘦素
抗精子抗体
抗子宫内膜抗体
infertile wormen
leptim
anti-sperm antibody（AsAb）
endomential antibody（EmAb）
