摘要
①目的探讨非家族性大肠腺瘤性息肉及腺癌中生存素（Survivin）及环氧化酶2（Cox-2）的表达。②方法收集我院2006年1月~2007年12月大肠腺瘤性息肉及腺癌标本,利用免疫组化技术分别检测40例腺瘤性息肉,40例大肠腺癌及相应的正常黏膜对照中Sur-vivin、Cox-2的表达情况。③结果Survivin及Cox-2在正常黏膜与腺瘤性息肉及腺癌中的表达依次增强,且均有统计学意义（P〈0.01）。④结论Survivin、Cox-2可能是大肠腺瘤发展及癌变过程中的重要促进因子,对于预测大肠腺瘤癌变可能性及化学干预有重要意义。
Objective To detect the expression of Survivin and Cox-2 in colonic adenomatous polyp and colon cancer.Methods The samples of colonic adenomatous polyp and colon cancer were collected from Jan 2006 to Dec 2007,and the expressions of Survivin protein and Cox-2 protein in 40 colonic adenomatous polyp,40 colon cancer and normal mucous membrane were examined with immunohistochemical staining.Results The expressions of Survivin and Cox-2 in normal mucous membrane,colonic adenomatous polyp and colon cancer were strengthened in turn,and there were significant difference among them（P0.01）.Conclusion Survivin and Cox-2 mould be a important stimulative factor in the progression of colonic adenomatous polyp and colon cancer,and it had important significance for predicting adenomatous polyposis canceration and chemical interfering canceration progress.
出处
《华北煤炭医学院学报》
2010年第1期9-10,共2页
Journal of North China Coal Medical College
