摘要
目的:明确小鼠呼出气体与吸入气体间存在容量差值,观察其对于体积描记箱内压力变化的影响。方法:用双室体积描记法测量8只麻醉小鼠呼吸时头室内压力和温度变化,计算吸入气体容量、呼出气体与吸入气体的容量差值。结果:头室内压力曲线的基线随描记箱内温度上升,约12 min后,尽管此时头室内温度仍保持高位,但压力基线开始缓慢下降。8只小鼠的吸入气体容量为(0.2842±0.0173)ml,呼出气体与吸入气体的容量差值为(0.0012±0.0002)ml。结论:小鼠的吸入气体容量大于呼出气体容量,二者的差值导致压力式描记箱内压力变化曲线基线缓慢下降。由于此差值远小于吸入气体容量,故在计算潮气量时可以对此差值忽略不计。呼吸商的存在,是此差值产生的原因。
Objective： To investigate the differential value of inhaled volume and exhaled volume in anesthesia mice,and its effect on the pressure change inside of plethysmograph.Methods： Pressure and temperature in head chamber of double-chamber plethysmograph were tested when mice were placed in the body chamber.The differential values of inhaled volume and exhaled volume of mice were calculated.Results： The baseline pressure in head chamber increased with temperature rising within 12 minutes,then went down though temperature remained high.The inhaled volumes of 8 mice were（0.2842±0.0173）ml,and the differential value of inhaled volume and exhaled volume was（0.0012±0.0002）ml.Conclusion： The inhaled volume is larger than exhaled volume,which makes pressure baseline of plethysmograph decreased.The differential value may be generated from respiratory quotient.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2010年第3期322-325,共4页
Journal of Zhejiang University(Medical Sciences)
关键词
呼吸
潮气量
压力
温度
Respiration
Tidal volume
Pressure
Temperature
