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血啉甲醚-光动力疗法(PDT)对大鼠脑胶质瘤血瘤屏障上p-糖蛋白的表达影响

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摘要 目的研究光动力作用后C6胶质瘤后,血瘤屏障上的p-糖蛋白(p-gp)的表达,观察光动力对脑胶质瘤血肿瘤屏障上的p-gp表达的影响。方法体外培养C6胶质瘤细胞,按Peterson法,将C6胶质瘤细胞接种于大鼠右侧尾壳核,复制脑深部胶质瘤模型,2周后对鼠脑胶质瘤和鼠脑进行光动力处理,免役组织化学方法研究血瘤屏障上的p-糖蛋白的表达。结果 40例鼠脑胶质瘤模型,光动力处理组p-gp阳性表达率为10%,非光动力处理组p-gp阳性表达率为40%,提示光动力处理组与非光动力处理组之间存在有显著性差异(P<0.05,χ2=4.8)。结论光动力作用后血瘤屏障上的p-gp阳性表达率降低。
出处 《齐齐哈尔医学院学报》 2010年第8期1212-1213,共2页 Journal of Qiqihar Medical University
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