摘要
目的探讨糖化血红蛋白(HbA_1c)在妊娠糖尿病(GDM)筛查与诊断中的价值。方法对1815例50g葡萄糖负荷试验(GCT)阳性的孕妇同时测定3hOGTT及HbA_1c,比较糖耐量正常(NGT)组、妊娠糖耐量减低(GIGT)组和GDM组HbA_1c分布情况,并计算ROC曲线下面积(AUC)。结果 3组HbA_1c分布几乎重叠,ROC曲线下面积(AUC)为0.658,95%可信区间为[0.626,0.690]。结论 HbA_1c不适用于GDM的早期筛查与诊断。
Objective To investigate the value of HbA1c in the screening and diagnosing of gestational diabetes mellitus（GDM）. Methods 3h OGTT and HbAlc assay were performed in 1815 pregnant women with positive results of 50g glucose challenge test（GCT）. HbA1c distributions in subjects with normal glucose tolerance （NGT）, gestational impared glucose tolerance （GIGT） and GDM were compared, and area under curve（AUC） of receiver operating characteristie（ROC） curve was calculated. Results There was considerable overlap in HbA1c distributions among three groups. AUC of ROC curve was 0. 658, 95% confidence interval（CI） was 0. 626-0. 690. Conclusions HbA1c does not apply to the screening and diagnosing of gestational diabetes in early stage.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2010年第6期438-440,共3页
Chinese Journal of Diabetes
基金
国家科技支撑计划项目(2008BAI58B02)
关键词
糖尿病
妊娠
糖化血红蛋白
Diabetes mellitus, gestational
Glycosylated hemoglobin
