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消渴和胃方促进糖尿病鼠胃排空的实验研究

Experimental Research on XiaoKeHeWei Decoction to Encouraging Gastric Emptying of the Diabetic Rats.
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摘要 目的:证实"消渴和胃"方可有效缓解糖尿病鼠胃轻瘫,促进胃排空,并初步探讨其作用机制。方法:110只实验鼠随机分成四组:对照组20只,糖尿病+中药组30只,糖尿病+胃复安组30只,单纯糖尿病组30只。饲养12周后,观察以下项目:①13C呼气实验法测定胃内固体半排空时间;②胃内残留甲基橙液体量;③胃壁肌间神经丛数;④胃壁平滑肌厚度。结果:①与对照组比较,糖尿病鼠的胃壁肌间神经丛数明显减少,平滑肌厚度明显变薄,固体及液体的排空时间明显延长;②给予中药或胃复安治疗可明显改善糖尿病鼠的胃排空速度(P<0.01,P<0.05);③中药组胃壁神经丛数及平滑肌厚度均高于胃复安组(P<0.01,P<0.05),对糖尿病鼠胃固体排空的改善效果优于胃复安组(P<0.05)。结论:"消渴和胃方"可有效促进糖尿病鼠胃动力,固体排空效果优于传统全胃肠动力药胃复安,为糖尿病胃轻瘫提供了新的治疗途径。 Objective: To study the effect of Chinese Medicine decoction composed of Chenpi, Muxiang, Zhishi, Xiangfu on Gastric Emptying of Diabetic Rats and illustrate the mechanism of it. Methods : One hundred and ten rats, were randomly divided into normal group ( n = 20), diabetes group ( n = 30), Western Medicine group ( n = 30 ) and Chinese Medicine group ( n = 30) . Blood sugar of group A is normal and the random blood sugar of the other three groups was controlled around about 25mmol/L. After feeding 12 weeks later, all rats were forbidden to eat in 24 hours, feeded standard 13c -caprylic -egg yellow substrate test meal, calculate the time of substrate evacuation. After that, all rats were absolutely non - dieted 24 hours again, be killed 20 minutes later after pouring 2ml 0. 1% methyl orange, opaunch and taking out the stomach, observing gastric empty- ing and the stomach pathological changes under the microscope. Results: The gastric emptying of diabetes groups/rats were obvi- ously delayed in compared with normal groupones. After therapy of qi - regulating Chinese Medicine, the gastric motility of diabetic rats was improved evidently, better than the western medicine group. The gastric myenteric plexus and thickness of smooth muscle of diabetes groups were all descended, and they were improved after treated with Chinese Medicine, but the western medicine group changed little. Conclusions : Chinese Medicine improved the gastric motility of diabetic rats effectlly, especially to improve the solid evacuation velocity, Chinese Medicine was better than weifu'adn.
出处 《四川中医》 2010年第6期15-17,共3页 Journal of Sichuan of Traditional Chinese Medicine
关键词 糖尿病动物 胃轻瘫 消渴和胃方 Chinese Medicine diabetic rats gastroplegia
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