摘要
目的：为评价洛赛克对肝源性溃疡（ＨＵ）的疗效。方法：对２５１例肝硬化经胃镜检出溃疡的４８例患者，予每日晨服洛赛克２０ｍｇ，疗程４～６周，着重观察胃镜下溃疡愈合情况，并与同期消化性溃疡（ＰＵ）疗效对比分析。结果：４周愈合率ＨＵ组中，十二指肠溃疡（ＤＵ）为６ ９．２％（１８／２６），胃溃疡（ＧＵ）为５２．９％（９／１７）；ＰＵ组中ＤＵ与ＧＵ均为１００％（３１／３１，６／６）．两组比较具有显著性差异（ Ｐ＜０．０１）。６周愈合率 ＨＵ中 ＤＵ为 ８４．６％（２２／２６），ＧＵ为 ８２．３％（１４／１７）。肝功能 ＣｈｉｌｄＣ级者溃疡愈合率明显降低。结论：洛赛克治疗ＨＵ疗效满意，但疗程宜较ＰＵ长。ＨＵ的愈合于Ｃ级患者较低。
Objective:To evaluate the effect of Losec in the treatment of hepatogenic ulcer (HU). Methods: Forty-eight patients of HU received Losec in a dose of 20mg once a day for 4-6 weeks. The healing of HU was observed by endoscopy in comparision with peptic ulcer(PU),Results: In patients of HU,the overall healing rates for duodenal ulcer duodenal ulcer (DU ) after 4 wks treatment was 69. 2% (18/26). the rates for gastric nice (Gu) 52. 9 % (9/17). In patients of PU, the overall healing rates for both DU and GU were 100% (31/31 , 6/6 ), with significant difference (P＜0.01) compared to HU group. Conclusion: Our data showed that the effect of Losec in treatment of HU was satisfactory,but course of treatment was longer in comparision with that in patients of PU. However,the healing rate in patients with Child C group was relatively low.
出处
《重庆医学》
CAS
CSCD
1999年第2期97-98,共2页
Chongqing medicine
