摘要
应用NADPH脱氢酶反应(NADPHd反应)显示SD大鼠黑质纹状体系统内一氧化氮合酶(NOS)阳性细胞和末梢,用计算机图像灰度仪测其染色强度。结果:正常大鼠纹状体内存在的阳性神经元和末梢分布位置不同;高密度末梢分布于纹状体腹外侧缘,此区细胞数亦较多;低密度区分布于纹状体背内侧区,阳性细胞数亦较少。苍白球、丘脑和黑质未见NOS阳性物质。
The activites of nitric oxide synthase(NOS) in cell bodies and terminals of neurons in the nigro striatal system were detected by using a histochemical method of nicotinamide adenosine dinucleotide phosphate diaphorase (NADPH d) reaction in brain sections of the SD rat. The number of NOS positive neurons and density of the NOS positive terminals were counted under a DMRP biomicroscope. It was shown that the higher density of labled terminals and more labled neurons were located in the ventrolateral part of the striatum, while the lower density of terminals and less neurons in the dorsomedial part of the striatum. There were no terminals labled in the globus pallidus, substantial negra and thalamus. The results showed that the distributions of NOS positive neurons may have certain functional significance for motor regulation and certain parts of NOS positive terminals may be projected from the cerebral cortex.
出处
《首都医科大学学报》
CAS
1999年第1期14-16,共3页
Journal of Capital Medical University