摘要
目的探讨蓖麻油引产餐用于足月妊娠引产时，血清中雌孕激素、皮质醇及胎盘泌乳素水平变化，阐明蓖麻油引产餐发动分娩的内分泌机制。方法应用放射免疫法测定足月妊娠引产５７例血清相关激素水平，其中成功引产３２例（Ａ组），未成功２５例（Ｂ组），分娩自然发动３４例（Ｃ组）。结果Ａ组在不同时期（临产前、临产时、临产后）血清中皮质醇（Ｃｏ）及胎盘泌乳素（ＨＰＬ）水平均有显著上升（Ｐ＜０．０１），且与Ｃ组一致；Ａ组３个不同时期血清雌二醇（Ｅ２）、雌三醇（Ｅ３）水平有不同程度上升，孕酮（Ｐｒ）下降，但无显著性（Ｐ＞０．０５）；Ａ组临产时Ｃｏ，ＨＰＬ水平高于未成功组，差异显著（Ｐ＜０．０１），Ｅ２，Ｅ３及Ｐｒ水平无显著差异（Ｐ＞０．０５）。结论Ｃｏ、ＨＰＬ参与蓖麻油引产餐引产的发动，且与分娩的进展有关，未达到一定水平，分娩不能发动。
Objective\ To investigate the change of serum estradiol(E 2),estriol(E 3),progesterone(Pr),cortisol(Co),and human placental lactogen(HPL) concentrations during the inducement of castor oil meal in term birth and interpret the endocrine mechanism of inducement by caster oil meal.\ Methods\ To determine serum E 2,E 3,Pr,Co and HPL during the inducement by castor oil in 57 term birth by radio immunologial method,32 who had succeeded belong to group A,25 who had failed belong to group B,and 34 who gave birth by themselves belong to group C.\ Results\ The level of serum,Co,HPL increased apparently in each period(before labor, in labor and after labor) in group A.\ The level was same with that of group C.\ Although E 2,E 3 and Pr increased or decreased(Pr) in group A,there was not significantly different.\ The level of Co and HPL in group A was higher than that of group B and the difference was significant.\ The difference of the level of E 2,E 3 and Pr wasn't significant.\ Conclusion\ Co and HPL contributed to the start of birth in the inducement of caster oil meal and was correlated with the development of labor.\ The labor can't be started and inducement would fail if they havn't achieve some levels.\ Our research can't prove if E and Pr was correlated with labor. \ They play important role in part of uterus.
出处
《福建医科大学学报》
1999年第1期58-60,共3页
Journal of Fujian Medical University
关键词
妊娠
蓖麻油
引产
药物引产
pregnancy
inducement, caster oil
hormones
