摘要
为了研究脉冲电场作用下细菌细胞膜响应,建立了单个细菌的球状模型,通过求解拉普拉斯方程推导跨膜电压表达式。根据表达式进行了跨膜电压的频域和时域分析。通过分析表达式中跨膜电压与外电场间的传递函数,得到跨膜电压的频域特性;通过对表达式进行拉普拉斯变换与反变换,求解出跨膜电压的时域特性。频域分析结果表明,外电场作用下的细菌细胞膜体现出低通滤波器的特性。时域分析结果表明,方波脉冲作用下的跨膜电压幅值与脉宽有关;单指数衰减波脉冲作用下的跨膜电压幅值与衰减时间常数有关;振荡衰减波脉冲作用下的跨膜电压幅值与振荡频率有关。
In order to solve the response of bacterial membrane in pulsed electric field,a single spherical model of bacterium was built. The transmembrane voltage expression was derived by solving the Laplace’ s equation. The transmembrane voltage was also analyzed in frequency domain and time domain according to the expression. By analyzing transfer function of transmembrane voltage and outer electric field in the expression,the frequency domain characteristic was derived. By Laplace transforming and inverse La-place transforming the expression,the time domain characteristic was derived. The result of frequency domain analysis shows that bacterial membrane represents low-pass filter characteristic in pulsed electric field. The result of time domain analysis shows that the transmembrane voltage amplitude in square wave, exponential decaying wave,and oscillation wave pulsed electric field are related to the pulse width,deca-ying time constant,oscillating frequency respectively.
出处
《电机与控制学报》
EI
CSCD
北大核心
2010年第5期84-90,共7页
Electric Machines and Control
基金
国家自然科学基金(50877020)
黑龙江省新世纪优秀人才支持计划(NCET2062008)
关键词
脉冲电场
跨膜电压
频域分析
时域分析
pulsed electric field
transmembrane voltage
frequency domain analysis
time domain anal-ysis
