摘要
目的研究p21^(waf1)在贲门癌中的表达状况,分析其表达与临床病理特征及生存之间的关系,进一步探讨贲门癌的发病机制。方法应用免疫组化及组织芯片技术,对78例贲门癌组织中的p21^(waf1)蛋白表达情况进行分析。结果贲门癌中p21^(waf1)蛋白的阳性表达率为65.4%,其表达与肿瘤分化程度、浸润深度和Lauren分型有关(均P<0.05)。Kaplan-Meier生存分析表明,p21^(waf1)表达与贲门癌患者的预后相关(P<0.05)。结论同正常对照组相比,贲门癌中p21^(waf1)蛋白的表达水平升高,其表达与贲门癌的生物学行为密切相关,阳性表达患者预后优于阴性者,但尚不能作为一个独立的预后指标。
Objective To evaluate the expression pattern of p21^waf1 protein in cardia gastric cancer, to determine the relationship between p21^waf1 and tumor clinicopathological features as well as patient survival and to probe into its pathogenesis. Methods The tissue microarrays were used to determine p21^waf1 protein expression by immunohistochemistry S-P in 78 cardia cancer cases. Results The positive expression rate of p21^waf1 protein in cardia gastric cancer was 65.43. p21^waf1 expression was found to be statistically related to the tumor differentiation status, depth of invasion and Lauren classification in cardia gastric cancer （P 〈0.05）. Kaplan-Meier analysis showed that p21^waf1 expression was related to the patient survival （P 〈0.05）. Conclusion There exists higher level expression of p21^waf1 protein in cardia gastric cancer compared with the controls. The expression of p21^waf1 protein is closely related to the bio-behaviors in cardia gastric cancer. The p21^waf1 positive-expressed patients has a good survival than those of negative expressed, however, it is still not an independent prognosis factor.
出处
《兰州大学学报（医学版）》
CAS
2010年第2期8-11,共4页
Journal of Lanzhou University（Medical Sciences）
基金
国家自然科学基金(30872478)
