摘要
目的:研究IL-17在再生障碍性贫血(AA)发病中的作用,进一步明确AA的发病机理,为新的研究治疗提供理论依据。方法:采用ELISA方法分别检测AA初发、缓解患者及健康人(对照组)的血清IL-17水平。用RT-PCR法检测AA患者与正常对照组外周血T细胞mRNA表达。结果:AA初发时体内血清IL-17水平及IL-17mRNA显著高于正常对照组及缓解后(P<0.01);AA缓解后血清IL-17及IL-17mRNA的表达与正常对照组相比无显著性差异(P>0.05)。结论:IL-17在AA发病机理中可能起重要调节作用,抗IL-17抗体生物治疗有望成为治疗AA的新方法。
Objective：To investigate the Pathogenesis of Aplastic Anemia（AA） and evaluate the role of IL-17 in AA.Methods：The level of IL-17 in the peripheral blood of three groups of people {the patients with AA before therapy,the patients with AA who achieved partial remission（PR） or complete remission（CR） and the healthy donors}was evaluated by flow ELISA.The level of IL-17mRNA expression of each group was examined by RT-PCR.Results：The level of IL-17 and the level of IL-17mRNA expression in the patients with AA before therapy was significantly higher than that of the healthy donors and the patients after remission.The level of IL-17 and the level of IL-17mRNA expression in the patients with remission was No statistical significance compared with that in the healthy donors.Conclusion：IL-17 plays an important role in the occurrence of aplastic anemia.
出处
《现代临床医学》
2010年第3期176-177,共2页
Journal of Modern Clinical Medicine
