摘要
目的观察含硼替佐米为主化疗方案治疗多发性骨髓瘤(MM)的毒副作用及处理方法。方法回顾分析20例含硼替佐米为主方案治疗MM的临床资料,按国际肿瘤组织的毒性判定标准评价不良反应。结果发生胃肠道反应10例,白细胞减少11例,血小板减少13例,周围神经病变症状9例,感染14例,经对症、暂时停药后均有所改善。出现少见不良反应抗利尿激素分泌失调综合征1例、急性心功能不全1例。结论硼替佐米为主化疗方案治疗MM毒副作用患者基本可耐受,但也有少见不良反应的发生,需要引起重视。
Objective To summarize the adverse effects and treatments of bortezomib combined regimen in treatment of multiple myeloma（MM）.Methods Data of 20 patients with multiple myeloma diagnosed by NCI-CTCAE（3.0 version） were retrospectively analyzed.Results The incidences of main drug-related toxicities were 50% for gastrointestinal-reactions,55% for leukopenia,65% for thrombocytopenia,45% for peripheral-neuropathy and 70% for infection.The adverse effects could be relieved by symptomatic treatment or suspended chemotherapy.There was one case with the syndrome of inappropriate secretion of antidiuretic hormone （SIADH） and one case with acute cardiac insufficiency.Conclusion The bortezomib combined regimen could be tolerable and safe in most MM patients,but attention should be paied to some rare adverse effects.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第10期1158-1159,共2页
Jiangsu Medical Journal
