摘要
目的：探讨肝细胞肝癌组织中PTTG蛋白和Survivin蛋白的表达及相互关系.方法采用免疫组织化学SP法检测40例肝癌组织、癌旁组织及10例正常肝组织中PTTG和Survivin蛋白的表达.结果：在肝细胞肝癌组织、癌旁组织中,PTTG蛋白和Survivin蛋白表达的阳性率分别为77.5%%（31/40）、92.5%（37/40）,57.5%（23/40）、27.5%（11/40）, 正常肝组织均未见表达.结论：PTTG蛋白和Survivin蛋白的异常表达与肝细胞肝癌的发生和发展密切相关,为肝细胞肝癌的早期诊断和基因治疗提供新的途径.
Objective To investigate the expression and the relationship of PTTG and Survivin protein in hepatocellular carcinoma. Metheds The expression of PTTG and Survivin protein was detected by immunohistochemistrical assay in 40 cases of human hepatocellular carcinomas,neighboring noncancerous tissue and 10 cases normal livers tissues. Results The positive rate of PTTG protein and Survivin protein in hepatocellular carcmoma and neighboring noncancerous tissue were 77.5%（31/40）,92.5%（37/40） ,57.5%（23/40）,27. 5%（11/40） while it was negative in normal Liver tissue. Conclusions The abnomal expression of PTTG gene and Survivin gene in human hepatocellular carcinomas suggested that they may play an important role in the process of carcinogenesis and may provide a new approach in liver cancer early diagnosis and gene therapy.
