摘要
目的：观察精制蝮蛇抗栓酶治疗小儿急性偏瘫的临床疗效。方法：１２８例急性小儿偏瘫患儿随机分为２组，对照组６４例给予低分子右旋糖酐１０ｍｌ·ｋｇ－１·ｄ－１加复方丹参注射液４～６ｍｌ静滴；治疗组６４例给予精制蝮蛇抗栓酶０．０１０～０．０１２Ｕ·ｋｇ－１·ｄ－１加生理盐水１００ｍｌ静滴。２组常规治疗相同，均以１４日为１个疗程，酌情用２～３个疗程。结果：治疗组总有效率（９５．３％）明显高于对照组（６８．８％），ｕ＝９．４６，Ｐ＜０．００１；病死率（３．１％）明显低于对照组（１２．５％），ｕ＝３．９１，Ｐ＜０．０５。经过２年的追踪随访，治疗组各种后遗症的发生率均明显低于对照组（Ｐ均＜０．０５）。结论：精制蝮蛇抗栓酶治疗小儿急性偏瘫临床疗效较好，优于传统扩血管剂，无明显不良反应。
Objective:To observe the clinically curative efficacy treated with svate3 for acute hemiplegia in infancy and childhood.Methods:128 cases of infancy and childhood with acute hemiplegia were randomly divided into two groups.Control group ( n =64) was treated with low molecular dextran 10 ml·kg -1 ·d -1 and composite salvia miltiorrhiza injection 46 ml infused intravenously,treatment group ( n=64 ) treated with svate3 0 0100 012 U·kg -1 ·d -1 +N.S 100 ml infused intravenously.The conventional treatments were similiar in both group.14 days were one therapeutic course for both groups and 2 or 3 courses could be used according the situations.Results:Total effective rate (95 3%) in treatment group was significantly higher than that (68 8%) in control group, u =9 46, P <0 001;and mortality rate (3 1%) markedly lower than that (12 5%), u =3 91, P <0 05.During the period of 2year followup the accurance rate of sequela in treatment group was significantly lower than that in control group (all P <0 05).Conclusions:The clinically curative efficacy treated with svate3 for acute hemiplegia in infancy and childhood is better,and more superior than that treated with traditional vascular dilators.There is no obvious sideeffects.It is worthy to spread.
关键词
偏瘫
急性
蝮蛇抗栓酶
右旋糖酐
儿童
复方丹参
acute hemiplegia in infancy and childhood\ \ svate3\ \ molecular dextran\ \ composite salvia miltiorrhiza injection
