摘要
目的：探讨β七叶皂甙钠与甘露醇对降低急性颅脑外伤患者颅内压（ＩＣＰ）的疗效和利尿作用的比较。方法：５０例急性颅脑外伤患者（观察组）伤后应用β七叶皂甙钠２０ｍｇ加生理盐水５０ｍｌ静注，每日总量６０ｍｇ，连用７日。对照组２０例应用２０％甘露醇２５０ｍｌ静注，每日２～３次，连用７日。检测２组患者ＩＣＰ变化及尿量、尿比重变化。结果：β七叶皂甙钠降ＩＣＰ作用的起效时间、作用高峰时间和作用持续时间〔分别为（０．５５±０．３１）ｈ、（２．３０±０．５０）ｈ和（５．３０±１．９６）ｈ〕与２０％甘露醇的作用〔分别为（０．４０±０．１２）ｈ、（０．８６±０．５４）ｈ和（４．２３±１．５０）ｈ〕比较，均有显著性差异（Ｐ＜０．０５，Ｐ＜０．００１和Ｐ＜０．０１）。利尿作用和血电解质、生化指标变化，２组均无显著性差异。结论：β七叶皂甙钠降低急性颅脑外伤患者ＩＣＰ作用明显，作用持续时间长于甘露醇，对肾脏损害作用小。
Objective:To evaluate the comparison of curative effects on depressing intracranial pressure(ICP) and diuretic action for patients with acute craniocerebral injury between sodium Aescinate and mannitol.Methods:50 cases with acute craniocerebral injury as observative group were treated with sodium Aescinate 20 mg +N.S 50 ml injected intravenously,total doses 60 mg a day for 7 days,and 20 cases treated with 20% mannitol 250 ml infused intravenously 23 times a day as control group.The variations in ICP,urinary volume and spacific gravity were mornitered for all the patients of two groups.Results:Using sodium Aescinate,the starting (0 55±0 31)h ,peak (2 30±0 50)h ,and continuous time (5 30±1 96)h ,respectively,for depressing ICP was significantly different from those (0 40±0 12)h,(0 86±0 54)h and (4 23±1 50)h using 20% mannitol ( P <0 05, P <0 001 and P <0 01,respectively).There was not significantly different in the aspect of diuresis,variations of electrolytes and biochemical parameters between two groups.Conclusions:The effects of sodium Aescinate on depressing ICP for patients with acute craniocerebral injury is very obvious,the continuous time of action of sodium Aescinate is longer than that of mannitol and the harm of it to kidneys is little.
关键词
Β-七叶皂甙钠
甘露醇
颅脑外伤
急性
颅内压
sodium Aescinate\ \ mannitol\ \ acute craniocerebral injury\ \ intracranial pressure
