摘要
目的:探讨心脏原发性恶性纤维组织细胞瘤的病理诊断和临床病理特点。方法:对1例心脏原发性恶性纤维组织细胞瘤进行光镜观察和免疫组织化学标记,并复习相关文献。结果:肿瘤位于左心房后壁,呈3个分叶,长径2.0～4.5cm。镜检见瘤细胞大多为梭形,呈束状排列,可见黏液样基质,薄壁血管丰富,间质见显著慢性炎细胞浸润。免疫表型:瘤细胞vimentin(),CD68(+),Ki-67(,>50%),SMA(+,灶性),S-100蛋白(+),CD34(-),desmin(-)。结论:心脏恶性纤维组织细胞瘤临床易误诊为心房黏液瘤,要依据形态特征及免疫表型方可确诊。本瘤恶性程度高,易复发,预后不佳。
Objective：To investigate the pathological diagnosis and pathological characteristics of primary heart malignant fibrous histiocytoma.Methods：One case of primary cardiac malignant fibrous histiocytoma was observed by light microscopy and immunohistochemistry,and the literature was reviewed.Results：The tumor which was divided into three sub-leaves was located on the posterior wall of the left atrium,with a maximal diameter of 2.0 to 4.5 cm;microscopically,the tumor cells were mostly in the shape of spindle,showing fascicular arrangement;myxo-matrix,rich blood vessels and interstitial chronic inflammatory cell infiltration could be observed.Immunophenotype showed tumor cells of vimentin strongly positive,CD68,Ki-67（〉50%）,SMA（focal）and S-100 protein positive,CD34 and desmin negative.Conclusions：Cardiac malignant fibrous histiocytoma is frequently misdiagnosed as atrial myxoma;correct diagnosis should be based on pathological examination and immunohistochemistry.This tumor is highly malignant,easy to relapse and has a poor prognosis.
出处
《蚌埠医学院学报》
CAS
2010年第5期469-471,共3页
Journal of Bengbu Medical College
关键词
心脏肿瘤
恶性纤维组织细胞瘤
病理学
临床
免疫组织化学
heart neoplasms
malignant fibrous histiocytoma
pathematology
clinical
immunohistochemistry
