摘要
目的探讨红黄洗液外用预防留置针输注甘露醇所致外周静脉损伤的效果。方法将30只新西兰白兔随机分为A、B两组各15只,取其双侧耳缘静脉置入留置针。A组左耳(红黄洗液组)注射常温(20℃)20%甘露醇,同时涂搽红黄洗液;右耳(乙醇组)涂搽75%乙醇。B组左耳(加温组)静脉注射加温至35℃20%甘露醇;右耳(对照组)静脉注射常温20%甘露醇。均为2次/d,间隔6h,连续5d。实验期间肉眼观察静脉炎发生情况,实验结束后行病理组织学分析。结果肉眼观察红黄洗液组静脉损伤评分显著低于另三组(均P<0.05)。病理分析,针体段炎细胞浸润、纤维组织增生四组比较,差异有统计学意义(均P<0.05);针体前段血管壁损伤、炎细胞浸润、纤维组织增生及血栓形成四组比较,差异有统计学意义(P<0.05,P<0.01)。结论采用留置针静脉注射20%甘露醇对兔耳缘静脉有不同程度的损伤,以针体前段更甚,用红黄洗液涂搽局部预防效果优于涂搽75%乙醇及液体加温法。
Objective To explore the effect of Honghuang lotion on preventing phlebitis caused by mannitol infused through indwe- lling catheters. Methods Thirty rabbits were randomized into two groups of 15, receiving indwelling intravenous catheters through auricular vein of both sides. In group A, the left ears were infused 20% mannitol at 20 degree centigrade, and Honghuang lotion was applied during infusion （Honghuang lotion group） ; the right ears were given 75% alcohol during infusion （alcohol group）. The group B were infused 20% mannitol at 35℃ （heated group） or at 20℃ （control group） through the left or right ears respectively. The infusion frequency was twice per day with the interval being 6 h, lasted 5 days. The occurrence of phlebitis was observed by naked eye, and in the end histopathological analysis was done. Results The score of vascular injury of Honghuang group was significantly lower than those of the other groups observed by naked eye （P〈0.05 for all）. Histopathological analysis showed that inflammatory cell infiltration and fibrous tissue proliferation at the body of the catheters had significant differences among the 4 groups （P〈0.05 for both） ; the vascular wall injury, inflammatory cell infiltration, fibrous tissue proliferation and thrombosis at anterior segment of the catheter demonstrated significant differences among the 4 groups （P〈0.05, P〈0.01）. Conclusion Rabbitsr veins suffer from some degree of damage during infusion of 20%mannitol through indwelling catheters, especially at the anterior segment of the catheters. The efficacy of Honghuang lotion on prevention of phlebitis is better than that of alcohol or infusion of heated mannitol.
出处
《护理学杂志（综合版）》
2010年第6期11-14,共4页
Journal of Nursing Science
关键词
白兔
静脉炎
甘露醇
红黄洗液
乙醇
加温
动物实验
rabbit
phlebitis
mannitol
Honghuang lotion
alcohol
warm up
animal experiment
