摘要
microRNAs(miRNAs)是一种长度为19-24个核苷酸的单链非编码RNAs,他们通过下调基因表达广泛参与各种重要的生命进程,如细胞凋亡、分化、增殖及个体发育等.最近研究表明,miRNAs可调控许多参与大肠癌(colorectal cancer,CRC)发生发展的癌基因和抑癌基因通路,如Wnt/β-连环蛋白,KRAS,磷脂酰肌醇(3)-激酶(PI3-K)和P53信号通路等.此外,单核苷酸多态性(SNPs)对CRC中miRNAs表达的影响及miRNAs在CRC表观遗传学改变中的作用也日益受到人们的关注.本文将就miRNAs调控网络在CRC发生发展中的作用作一综述.
MicroRNAs（miRNAs） are single-stranded noncoding RNAs,typically 19-24 nucleotides in length.By down-regulating gene expression,they widely participate in a variety of important life processes,such as apoptosis,differentiation,proliferation and development.Recent studies have shown that miRNAs can control many oncogene and tumor suppressor pathways that are involved in the development and progression of colorectal cancer（CRC）,such as the Wnt/β-catenin,K-ras,phosphatidylinositol-3kinase（PI3-K）,and P53 signaling pathways.In addition,the research on the effects of single nucleotide polymorphisms（SNPs） on miRNA expression and the epigenetic regulation of microRNAs in CRC has attracted much attention from researchers.This paper will review the role of microRNA regulatory network in the pathogenesis of CRC.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第14期1478-1484,共7页
World Chinese Journal of Digestology
基金
上海市科委基金资助项目
No.07DZ19505~~
关键词
微小RNAS
调控网络
信号通路
大肠癌
发病机制
MicroRNA
Regulatory network
Signal-ing pathway
Colorectal cancer
Pathogenesis
