摘要
目的:探讨STAT3基因在急性淋巴细胞白血病发生发展中的作用。方法:应用Western Blot法检测STAT3基因的蛋白水平。结果:急性淋巴细胞白血病骨髓单个核细胞中的P-STAT3基因蛋白水平表达明显高于正常人骨髓单个核细胞(P<005);而急性淋巴细胞白血病骨髓单个核细胞中的STAT3基因蛋白水平与正常人骨髓单个核细胞相比差异无统计学意义(P>005)。结论:STAT3基因的持续激活在急性白血病的发生发展中起重要作用,可作为早期诊断的指标及治疗的新靶点。
Objective To investigate the important role and significance of STAT3 gene during the progress of originating and developing of human acute lymphoblastic leukemia （ALL）.Methods Applying western blot to detect the protein expression of STAT3 gene.Results The protein expression of P-STAT3 gene is significant higher in ALL than in normal cell（P0.05）,and there is no significant difference between the protein expression of STAT3 gene and normal cell （ P〉0.05）.Conclusion The persistent activation of STAT3 gene plays an important role in the carcinogenesis of ALL,and STAT3 gene may be act as a new target in the diagnosis and therapy of ALL.
出处
《吉林医学》
CAS
2010年第15期2163-2164,共2页
Jilin Medical Journal
