摘要
目的探讨丙种球蛋白治疗不耐受川崎病患儿血清人免疫球蛋白(Ig)G亚型及肿瘤坏死因子(TNF)α的变化。方法选取2007年2月—2009年6月我院8例丙种球蛋白治疗不耐受川崎病患儿为观察组,同时选取同期10例非丙种球蛋白治疗不耐受川崎病患儿为对照组,测定两组患儿血清IgG1、IgG2、IgG4、TNF-α、C反应蛋白(CRP)及血浆清蛋白水平。结果观察组患儿血清IgG1及IgG4水平较对照组明显升高,差异均有统计学意义(P<0.05);观察组患儿血清IgG2水平较对照组明显降低,差异有统计学意义(P<0.05);观察组患儿血清TNF-α、CRP及血浆清蛋白水平较对照组明显升高,差异均有统计学意义(P<0.05)。结论丙种球蛋白治疗不耐受川崎病患儿血清IgG1、IgG2、IgG4、TNF-α、CRP及血浆清蛋白水平有其特有的变化,治疗时应引起相应注意。
Objective To study the changes of immunoglobulin G-subtypes and TNF-α in patients with Kawasaki disease who are intolerant to Gamma globulin.Methods Totally 8 patients with Kawasaki disease who were intolerant to gamma globulin in our hospital from February 2007 to June 2009 were selected as observation group,and 10 patients with Kawasaki disease who were intolerant to non-gamma globulin as control group.Serum IgG1,IgG2,IgG4,TNF-α,CRP,and plasma albumin were determined.Results Serum IgG1 and IgG4 were significantly higher and serum IgG2 was significantly lower in observation group than in control group （allP0.05）.Serum TNF-α,CRP,and plasma albumin significantly increased in the observation group（P0.05）.Conclusion Serum IgG1,IgG2,IgG4,TNF-α,CRP and plasma albumin can change in patients with Kawasaki disease who are intolerant to gamma globulin,which should be carefully considered during treatment.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第15期1691-1692,共2页
Chinese General Practice
关键词
丙种球蛋白
川崎病
免疫球蛋白
Gamma globulin
Kawasaki disease
Immunoglobulin
