摘要
目的:探讨影响冷冻胚胎复苏率和移植成功率的胚胎因素。方法:回顾性分析149个冷冻胚胎移植(frozen-thawed embryo transfer,FET)周期的临床资料,按胚胎发育时间、冷冻前胚胎质量、复苏后胚胎损伤情况分别进行分组,比较不同分类各组间的胚胎复苏情况和(或)临床妊娠率的差异。结果:受精第二天冷冻组与第三天冷冻组的胚胎复苏存活率和临床妊娠率比较,差异无统计学意义(P>0.05)。冷冻胚胎中有优质胚胎者的种植率和临床妊娠率均显著高于无优质胚胎者(P<0.05)。全部移植完整存活胚胎和混合移植组的临床妊娠率和种植率均显著高于全部移植受损胚胎者(P<0.05)。结论:冷冻前胚胎质量和复苏后胚胎卵裂球损伤程度是影响临床妊娠率的重要因素。
Objective： To explore the effect of embryo factors on post-thaw embryo survival rate and clinical pregnancy rate in frozen-thawed embryo transfer（FET） cycles.Methods：The clinical data of 149 cycles of FET were retrospectively analyzed.Groups were divided according to pre-freeze embryonic developmental stage,pre-freeze embryo quality and blastomere survival rates,respectively,and embryo survival rates and/or clinical pregnancy rates were compared among these groups.Results：There was no significant difference in the embryo survival rate and clinical pregnancy rates between embryos frozen on the 2 nd day of fertilization and those frozen on the 3rd day（P〉0.05）.The clinical pregnancy and implantation rates of high quality pre-freeze embryo were significantly higher than that of low quality pre-freeze embryo（P〈0.05）.The clinical pregnancy and implantation rates of transferred embryos with fully intact blastomere and with mixed embryos were significantly higher than that with partially damaged embryos（P〈0.05）.Conclusion：Pre-freeze embryo quality and blastomere survival status of post-thaw embryos were important factors influencing clinical outcome in FET cycles.
出处
《海南医学院学报》
CAS
2010年第5期604-607,共4页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(003020100167)~~
关键词
胚胎冷冻
复苏
临床妊娠率
Embryo cryopreservation
Resuscitation
Pregnancy rate
