摘要
为了研究红细胞增多对血液流变学和肺动脉高压的影响。同时观察普萘洛尔（心得安）对红细胞增多的治疗作用。将实验大鼠分为三组：对照组；氯化钴引起单纯红细胞增多组：红细胞增多加心得安组。结果发现，单纯红细胞增多引起肺动脉压、右室压增高，所有切变率下尤其低切变率下的全血粘度也增高，红细胞膜流动性降低，下肢肌肉血流量和体表温度下降。肺动脉压与红细胞压积和右室压之间有良好的正相关性。心得安对上述指标无改善作用。提示单纯红细胞增多即可形成肺功脉高压。而心得安对红强胞增多引起的血液流变学和肺动脉压的变化无影响。
Rats were divided into 3
groups,1.Control,2.Polycythemia induced by CoCl2 injection [10mg/(ip/kg·day)×
35days],3.Progranolol[1mg ip/(kg·day)。35days]was administrated in CoCl2polycythemia
rats.It was found that after long term CoCl2 injection,RBC,Hb,Hct increased withby
11.2%.123%and 133% respectively (all P<0.001,compared with control group).Blood viscos-ity
was increased also by 142%(high shear 6%,D40%)and 215%(low shear 1%,D8%).Pulmonary
artery pressure and right ventricular pressure increased 146% and 141% respectively
(allP<0.01),and the muscle and skin microcirculatory blood flow decrease respectivety(all
P<0.01).Result also indicated that propranolol showed no effect on polycythemia and pulmonary
artery hyper-tension induced by CoCl2.
出处
《基础医学与临床》
CSCD
1999年第1期56-59,共4页
Basic and Clinical Medicine
