摘要
促肾上腺皮质激素(ACTH)非依赖性Cushing综合征包括肾上腺皮质腺瘤、肾上腺皮质癌和肾上腺皮质结节样增生,其发病机制主要与基因突变(GNAS1、PRKAR1A和PDE11A)、异位受体表达、WNT通路异常激活及抑癌基因杂合丢失等诸多因素相关,该文就上述发病机制作一综述。
Adrenocorticotropic hormone（ACTH）-independent Cushing syndrome includes adrenocortical adenoma,adrenocortical carcinoma and adrenocortical nodular hyperplasia,the pathogenesis of which is related to genetic mutations（GNAS1,PRKAR1A and PDE11A）,expression of aberrant hormone receptors,dysfunction of WNT pathway and loss of heterozygosity of tumor suppressor gene.The pathogenesis mentioned above is introduced in this article.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第5期508-510,共3页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家自然科学基金(30771018)~~
