摘要
目的：探讨异甘草酸镁在乳腺癌化疗中预防肝损伤的疗效及毒性。方法：52例乳腺癌患者选用多西他赛＋阿霉素方案化疗，随机分为治疗组和对照组，治疗组26例，化疗的同时辅以异甘草酸镁护肝治疗，对照组26例，化疗时不行护肝治疗。结果：治疗组肝功能异常低于对照组，两组比较差异有显著性（P〈0．05）。结论：天睛甘美对预防化疗药物肝损伤有较好疗效，可作为化疗时的护肝药物之一，以保证化疗的顺利进行。
Objective To observe the efficiency of magnesium isoglycyrrhizinate preventing hepatic injury induced by chemothrapy in the treatment of breast cancer. Method 52 patients were randomize into treated group and control group, each 26 patients, magnesium isoglyeyrrhizinate were used for 7 days during chemotherapy in treated group; the liver-protective agents were not added during chemotherapy in control group. Result The rate of hepatic injury in the therapeutic group after chemotherapy was obviously lower than that of control group （P 〈 0.05）. Conclusion magnesium isoglycyrrhizinate has significantly effect to inhibit hepatic injury after chemotherapy in the patients with breast cancer, and can effective maintenance the continuity of chemtherapy.
关键词
异甘草酸镁
乳腺癌
化疗
肝损伤
magnesium isoglycyrrhizinate breast cancer chemotherapy hepatic injury
