摘要
目的:研究生物降解聚-DL-乳酸(PDLLA)自锁式捆绑带固定骨折的生物力学性能。方法:80只新西兰大白兔随机分为两组,建立股骨干非负重骨折动物模型,应用生物降解自锁式捆绑带固定骨折为实验组,钢丝固定骨折为对照组,分别于术后1、4、8、12周行生物力学检查进行比较。结果:捆绑带组在术后4、8、12周均比钢丝组的弯曲强度高,但4周、12周时P>0.05,无统计学差异,8周时P<0.05,提示有统计学差异。离体同种固定物不同时间段抗拉强度自身比较:钢丝固定术后4阶段抗拉强度比较P>0.05,任何两两比较都没有统计学差异,抗拉强度未随术后时间延长发生明显下降。捆绑带固定术后4周与术后1周比较P>0.05,抗拉强度无明显降低,但术后8周和术后12周时P<0.05,抗拉强度明显下降。结论:生物降解自锁式捆绑带在非负重骨折治疗中可发挥良好的固定作用。生物降解自锁式捆绑带降解时,应力传导促进了骨折的愈合。
Objective：To study the biomechanics function of self-locking cerclage band made of biodegradable material poly-DL-lactic acid（PDLLA） in the fixation of fractures.Methods：Eighty rabbits were divided into two groups. Femur fracture models were made.Fractures were fixed using biodegradable self-locking cerclage band in experimental group and metal fixation material in control group.The biomechanics was analyzed and compared after 1,4,8 and 12 weeks respectively.Results：The bending strength of experimental group is more stronger than that of control group after 4,8 and 12 weeks,but it was not statistically significant at 4 and 12 weeks（P0.05）.It was statistically significant at 8 weeks（P0.05）.The tensile strength of the same cerclage instrument was compared at different stage in vitro,and the result of the control group was not statistically significant at the four stage（P0.05）.Regarding the changes of tensile strength of the cerclage instrument at different stage,the result of the experimental group was not statistically significant after 1 and 4 weeks（P0.05）.However,the decrease of tensile strength was statistically significant after 8 and 12 weeks（P0.05）.Conculsion：Biodegradable self-locking cerclage band could be used in the treatment of non-weight-bearing fractures.The stress force conducting promotes healing of fracture when the self-locking biodegradable cerclage band degrades.
出处
《华西医学》
CAS
2009年第11期3012-3015,共4页
West China Medical Journal
关键词
聚-DL-乳酸
捆绑带
骨折固定
生物力学
poly-DL-lactic acid
cerclage band
fixation of fracture
biomechanics
