摘要
目的:建立测定复方氯唑沙宗片中氯唑沙宗血药浓度的方法,并进行其在健康人体药物动力学研究。方法:18名男性健康志愿者单剂量口服复方氯唑沙宗片,高效液相色谱法测定复方氯唑沙宗中氯唑沙宗的血药浓度。结果和结论:此法操作简便、结果可靠。复方氯唑沙宗片中的氯唑沙宗主要药物动力学参数分别为T_(1/2)(0.927±0.3747)h,Tmax(1.403±0.681)h,Cmax(21.063±5.748)mg/L,AUC_(0～6)(51.624±15.202)mg/(L·h),AUC_(0～(?))(53.201±15.142)mg/(L·h)。
Objective：Aim To investigate the pharmacokinetics of complex chlorzoxazone tablets in healthy volunteers. Methods：Eighteen male healthy subjects received a single dose of two pieces of complex chlorzoxazone tablets. The concentration of complex chlorzoxazone was determined by HPLC.Results and Conclusion：This study provided a simple and reliable assay which can be used to determine two component concentrations of complex chlorzoxazone tablets in human scrum.The main pharmacokinetic parameters of chlorzoxazone was as follows：T_（1/2）（0.927±0.3747）h, Tmax（1.403±0.681 ）h,Cmax（21.063±5.748） mg/L,AUC_（0～6）（51.624±15.202） mg/（L·h）.AUC_（0～5）（3.201±15.142） mg/（L·h）.
出处
《华西医学》
CAS
2009年第11期2921-2923,共3页
West China Medical Journal
