摘要
背景与目的近年来非吸烟人群的肺癌发病率有上升趋势,为了给临床工作提供更准确的依据,本研究分析了四川地区原发性非吸烟肺癌的主要危险因素。方法分别收集四川大学华西医院2009年3月-12月诊治的145例原发性非吸烟肺癌患者及145例非吸烟社区健康人群进行配对。结果单因素分析筛选出17个相关因素;多因素条件Logistic回归分析显示:被动吸烟史(OR=2.267,95%CI:1.231-4.177)、近10年内有搬入新近装修住房史(OR=5.080,95%CI:1.632-15.817)、非一级血缘亲属恶性肿瘤家族史(OR=7.937,95%CI:1.815-34.705)、无自我解压途径(OR=2.491,95%CI:1.230-4.738)、工作压力大(OR=5.769,95%CI:2.030-16.396)、睡眠质量差(OR=2.538,95%CI:1.277-4.861)为主要独立危险因素;体重指数较高(OR=0.419,95%CI:0.226-0.779)、喜食蔬菜水果(OR=0.344,95%CI:0.155-0.762)、经常参加体育锻炼(OR=0.507,95%CI:0.274-0.937)为可能的保护因素。结论四川地区原发性非吸烟肺癌的发生与被动吸烟史、有害环境接触史、恶性肿瘤家族史及精神心理因素等相关。
Background and objective The incidence of lung cancer in non-smokers is increasing in recent years. The aim of this investigation is to explore main risk factors of non-smoking primary lung cancers in Sichuan province in order to provide more accurate data for clinical. Methods One hundred and fourty-five non-smoking pairs of cases and 145 of controls were matched by age and sex. The patients were newly-diagnosed definitely as primary lung cancer at West China Hospital of Sichuan University from March to December 2009. Results Seventeen exposure factors were explored as epidemic agents for non-smoking lung cancer in Sichuan by using univariate analysis; mutivariate conditional Logistic regression analysis showed that passive smoking, moved into newly renovated homes over the past 10 years, family cancer history from second/ third-degree relatives, lack of emotion regulation, heavy work pressure and poor quality of sleep were main risk agents for the non-smoking lung cancer incidence with OR 2.267 （95%CI： 1.231-4.177）, 5.080 （95%CI： 1.632-15.817）, 7.937 （95%CI： 1.815-34.705）, 2.491 （95%CI： 1.230-4.738）, 5.769 （95%CI： 2.030-16.396）, 2.538 （95%CI： 1.277-4.861）, respectively. While higher body mass index, eating fruit and vegetable and regular participating in physical exercise might be protective factors with OR 0.419 （95%CI： 0.226-0.779）, 0.344 （95%CI： 0.155-0.762）, 0.507 （95%CI： 0.274-0.937）, respectively. Conclusion The occurrence of non-smoking primary lung cancer associated with a variety of exposure factors including passive smoking, history of exposure to harmful environmental, family cancer history, mental and psychological factors in Sichuan Province.
出处
《中国肺癌杂志》
CAS
2010年第5期511-516,共6页
Chinese Journal of Lung Cancer
关键词
肺肿瘤
流行病学
非吸烟
病例对照研究
危险因素
Lung neoplasms
Epidemiology
Non-smoking
Case-control study
Risk factors
