摘要
目的探讨CD44v6在乳腺浸润性导管癌组织中的表达及其临床意义。方法采用免疫组织化学方法检测66例乳腺浸润性导管癌组织中CD44v6的表达情况,分析其与雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)和人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)表达的关系及其临床病理意义。结果乳腺正常导管上皮和浸润性导管癌组织中CD44v6的阳性表达率分别为10.0%(1/10)和71.2%(47/66),乳腺浸润性导管癌组织中的阳性表达率明显高于乳腺正常导管上皮组织(P<0.05)。乳腺浸润性导管癌组织CD44v6阳性表达率与腋淋巴结转移状况、组织学分级和TNM分期呈正相关(P<0.05)。乳腺浸润性导管癌组织CD44v6阳性表达率在ER和PR阴性组中明显高于阳性组(P<0.05),而在HER2阳性组中明显高于阴性组(P<0.05)。结论 CD44v6可能在乳腺浸润性导管癌的发生发展过程中起作用。
Objective To explore the expression of CD44v6 in infitrating ductal carcinoma of breast and its clinical significance. Methods S-P immunohistochemical method was used to assess the expression of CD44v6 in 66 cases of infiltrating ductal carcinoma of breast. The relationship between CD44v6 expression and expression of estrogen receptor （ ER ）, progesterone receptor （ PR ）, human epidermal growth factor receptor 2 （HER2） was analysed. The clinicopathological significance of CD44v6 was also analysed. Results The positive expression rate of CD44v6 in normal ductal epithelium and infiltrating dnctal carcinoma of breast was 10.0% and 71.2% ,respectively. The positive rate of CD44v6 expression in infiltrating ductal carcinoma cases were significantly higher than those in normal ductal epithelium group（ P 〈 0.05 ）. The expression of CD44v6 in infiltrating ductal carcinoma was correlated significantly with axillary lymph node metastasis, histological grading, and TNM stages （ P 〈 0.05 ）. The expression of CD44v6 in infiltrating ductal carcinoma was correlated significantly with ER negativity, PR negativity, and HER2. positivity. Conclusion CD44v6 may play an important role in the development of infiltrating ductal carcinoma of breast.
出处
《河北医科大学学报》
CAS
2010年第5期562-565,共4页
Journal of Hebei Medical University
基金
河北省普通高校强势特色学科肿瘤学建设资助项目(200552)
