摘要
目的探讨不同海拔高血压病患者血清瘦素(Leptin,Lep)、脂联素(adiponectin,Adp)含量变化。方法采用酶联免疫吸附测定(ELISA)法检测不同海拔的高血压病患者(高海拔高血压组n=40,中度海拔高血压组n=40)及正常对照组(高海拔对照组n=40,中度海拔对照组n=40)血清Lep、Adp的含量。结果不同海拔高血压组血清Lep含量均高于正常对照组(1.868±0.872)μg/L vs(1.064±0.372)μg/L,(1.395±0.750)μg/L vs(0.771±0.336)μg/L(P<0.01),高海拔高血压组血清Lep含量高于中度海拔高血压组(1.868±0.872)μg/L vs(1.395±0.750)μg/L(P<0.01),高海拔正常对照组血清Lep含量高于中度海拔正常对照组(1.064±0.372)μg/L vs(0.771±0.336)μg/L(P<0.05)。不同海拔高血压组血清Adp含量均低于正常对照组(2.272±0.718)mg/L vs(2.743±0.781)mg/L,(2.611±0.784)mg/L vs(3.186±0.734)mg/L(P<0.01),高海拔高血压组血清Adp含量低于中度海拔高血压组(2.272±0.718)mg/L vs(2.611±0.784)mg/L(P<0.05),高海拔正常对照组血清Adp含量低于中度海拔正常对照组(2.743±0.781)mg/L vs(3.186±0.734)mg/L(P<0.01)。结论不同海拔高血压病患者较正常人血清Lep含量增高、Adp含量下降;随着海拔的升高高血压病患者与正常人血清Lep含量增高、Adp含量下降。
Objective To discuss the changes and significance of serum leptin（Lep） and adiponectin（Adp） contents of hypertensive patients at different altitudes. Methods The enzyme-linked immunosorbent assay（ELISA） was adopted to detect serum Lep and Adp contents of hypertensive patients at different altitudes （high altitude hypertensive group, n = 40, medium altitude hypertensive group, n = 40） and normal control groups （high altitude control group, n =40,medium altitude control group, n =40）. Results The serum Lep contents of the hypertensive groups at different altitudes were higher than those of normal control groups, （1. 868± 0. 872） μg/L vs （1. 064 ± 0. 372） μg/L（ P 〈0.01） ,（1. 395±0. 750） μg/L vs （0. 771±0. 336） μg/L（ P d0.01） ,the serum Lep content of the hypertensive group at high altitude was higher than that of the hypertensive group at medium altitude, （1. 868±0. 872） μg/L vs （1. 395±0. 750） μg/L（ P 〈0.01） ,and the serum Lep content of the normal control group at high altitude was higher than that of the normal control group at the medium altitude,（1. 064±0. 372） μg/L vs （0. 771±0. 336） μg/L （ P 〈0.05）. The serum Adp contents of the hypertensive group at different altitudes were lower than those of the normal control groups,（2.272±0.718） mg/L vs （2.743±0.781） mg/L（P 〈0.01）,（2.611±0.784） mg/L vs （3. 186±0. 734） mg/L（ P 〈0.01） ,the serum Adp content of the hypertensive group at high altitude was lower than that of the hypertension group at medium altitude,（2. 272±0. 718） mg/L vs （2. 611±0. 784） mg/L （ P 〈0.05） ,and the serum Adp content of the normal control group at high altitude was lower than that of the normal control group at the medium altitudes,（2.743±0.781） mg/L vs （3.186±0.734） mg/L （ P ±0.01）. Conclusion The serum Lep content of the hypertensive patients increases and the Adp content decreases compared with those of normal people at different altitudes. W
出处
《临床荟萃》
CAS
2010年第12期1039-1041,共3页
Clinical Focus
关键词
高血压
瘦素
脂联素
高海拔
hypertension
leptin
adiponectin
altitude
