摘要
目的观察厄贝沙坦治疗原发性高血压并左室肥厚的疗效。方法将原发性高血压并左室肥厚患者60例,随机分为厄贝沙坦组(30例,150mg/d)和贝那普利组(30例,10mg/d)。疗程为6个月,服药前后测血压和用超声心动图检测左心室舒张末期内径(LVDD)、左心室舒张末期室间隔厚度(LVDST)、左心室舒张末期后壁厚度(LVPWT)和左室质量指数(LVMI)。结果治疗6个月后,血压较治疗前有明显下降(P<0.05),且厄贝沙坦组血压明显低于依那普利组,差异有统计学意义(P<0.05)。治疗后的LVDD、LVST、LVPWT和LVMI均比治疗前的显著降低(均P<0.05)。且厄贝沙坦组LVD、LVST、LVPWT及LVMI稍低于贝那普利组,差异有统计学意义(P<0.05)。两组不良反应发生率均较低。结论贝沙坦能有效降低高血压、逆转左室肥厚,不良反应少。
Objective To investigate the clinical effects of irbesartan on left ventricle 0.1% procaine hydrochloride in normal saline 0. 1%hypertrophy （LVH） in patients with essential hypertension. Methods A total of 60 left ventricle hypertrophy in patients with essential hypertension patients were randomly divided into irbesartan group （30 cases, 150 mg/d） and benazepril group （30 cases, 10 mg/d）. 6 months was a course of treatment. Blood pressure was measured; LVDD, LVST, LVPWT and LVMI were examined before and after treatment. Results 6 months after treatment, blood pressure decreased compared with that before the treatment （P〈0.05）. Values of LVDD, LVST, LVPWT and LVMI were found significantly changed compared with values before the treatment （P〈0.05）. Blood pressure, LVDD, LVST, LVPWT and LVMI in irbesartan group were slightly decreased than those in benazepril group （P〈0.05）. Adverse reaction were rarely found in both groups. Conclusion Irbesartan a can effectively decrease blood pressure on left ventricle hypertrophy in patients with essential hypertension with few adverse reaction.
出处
《中国医药指南》
2010年第15期13-15,共3页
Guide of China Medicine
关键词
厄贝沙坦
原发性高血压
左心室肥厚
Irbesartan
Essential hypertension
Left ventricle hypertrophy
