摘要
目的探讨抗癫痫药物(ADEs)对癫痫儿童血清性激素水平的影响。方法应用化学发光免疫分析法对125例癫痫患儿进行血清性激素水平测定,并观察各组性激素水平的变化。结果①单药组中丙戊酸钠(VPA)组、托吡酯组(TPM)、左乙拉西坦组(LEV)和联合用药组(VPA+TPM、VPA+LEV、TPM+LEV)其血清睾酮(TSTO)水平有不同程度升高,分别与对照组比较有统计学意义(P<0.05);VPA组雌二醇(E2)降低(P>0.05)、TPM组E2升高(P<0.05)。各组其余4项性激素:孕酮(PRGE)、泌乳素(PRL)、促卵泡生成激素(FSHA)、促黄体生成激素(LH),没有明显变化。②各组服药6、12个月检测TSTO与对照组比较有升高(P<0.05);12和6个月比较TSTO有升高趋势(P>0.05);二者TPM组E2均有升高,但二者比较无统计学意义(P>0.05)。③本组性激素的变化在性别和年龄上无统计学差异。结论服用ADEs对癫痫儿童血清性激素水平有不同程度的影响,提示在治疗期间检测癫痫儿童血清性激素水平的必要性。
Objective To investigate the effect of antiepileptic on serum sex hormone levels in children with epilepsy. Methods Detect and observe the variance of serum sex hormone levels of the 125 children with epilepsy by application of chemiluminescence immunoassay. Result （1）The levels of TSTO in VPA group, TPM group, LEV group and combined treatment group increased compared with the control group, and had statistically significance （P〈0.05）. The levels of E2 in VPA group decreased compared with the control group, but hadn＇t statistically significance, while TPM group increased and had statistically significance （P〈0.05）.The others including PRGE, PRL, FSH and LH hadn＇t marked change. （2） The levels of TSTO of every treatment group after administration of antiepileptic 6 months and 12 months, increased and had statistically significance（P〈0.05）. The levels of 12 months were higher than that of 6 months, but had not statistically significance. The change of E2 in TPM group of different course of treatment hadn＇t statistically significance（P〉0.05）. （3） Changes of sex hormone in this study hadn＇t statistically significance in sex and age. Conclusion Administration of antiepileptic has an effect on children＇s serum sex hormone. We should monitor the variance of that,when we treat the children with epilepsy giving antiepileptic.
出处
《中国医药指南》
2010年第15期7-8,共2页
Guide of China Medicine
基金
哈尔滨市科技局科技创新人才研究专项基金(2008RFXQS016)
关键词
儿童
癫痫
性激素
抗癫痫药物
Children
Epilepsy
Sex hormone
Antiepileptic
