摘要
目的:观察小剂量螺内酯联合美托洛尔对慢性心力衰竭患者血浆NT-p roBNP、CRP水平及心功能的影响。方法:将71例慢性心力衰竭(心衰)患者随机分为治疗组和对照组,均予常规抗心衰治疗,治疗组加服小剂量螺内酯联合美托洛尔,疗程12周。治疗前后用彩超测定心功能指标左心室射血分数(LVEF),ELISA法和散射比浊法测定血浆N2末端脑钠肽前体(NT-p roBNP)、C反应蛋白(CRP)水平。结果:治疗后治疗组总有效率明显高于对照组,心功能指标LVEF明显升高,血浆NT-p roBNP、CRP水平均明显下降,P均<0.05;治疗组血浆NT-p roBNP与LVEF呈负相关(r=-0.75,P<0.05);血浆CRP水平与LVEF增加呈负相关(r=-0.433,P<0.05)。结论:小剂量螺内酯联合美托洛尔治疗慢性心衰效果确切,其主要作用机制为降低血浆NT-p roBNP、CRP水平和改善心功能。
Objective：To observe the the effect of low-dose spironolactone combined with metoprolol on plasma NT-p roBNP,CRP levels and cardiac function of patients with chronic heart failure.Methods：The chronic heart failure（CHF） patients were randomly divided into treatment group and control group,and they are therefore correspondingly routine anti-heart failure therapy,and the treatment group took low-dose spironolactone combined with metoprolol treatment for 12 weeks.ELISA was used to detect the content of N2 terminal pro-brain natriuretic peptide（NT-proBNP）,C-reactive protein（CRP） levels was measured by Nephelometry,and measured the cardiac function.Results：After treatment,the treatment group was significantly higher overall response rate than the control group,and the LVEF increased significantly,and plasma NT-proBNP and CRP were significantly decreased（P 0.05）.The plasma NT-p roBNP and LVEF was negatively correlated（r =-0.75,P 0.05） and plasma CRP levels were negatively correlated with LVEF increased（r =-0.433,P 0.05）.Conclusion：Low-dose spironolactone combined with metoprolol in the treatment of chronic heart failure have precise effect,the main mechanism is that they can reduce plasma NT-proBNP,CRP level and improve cardiac function.
出处
《现代生物医学进展》
CAS
2010年第8期1501-1502,1508,共3页
Progress in Modern Biomedicine
关键词
慢性心力衰竭
N2末端脑钠肽前体
C反应蛋白
美托洛尔
螺内酯
Chronic heart failure
N2 terminal pro-brain natriuretic peptide
C-reactive protein
metoprolol
spironolactone
