摘要
目的探讨氯丙咪嗪对强迫症患者认知功能的影响。方法对符合DSM-IV及ICD-10强迫症诊断标准的37例强迫症患者在治疗前、治疗10周后分别采用神经心理测验（包括知识、算术、数字符号、木块拼图、数字广度、逻辑记忆、视觉记忆、Stroop test、词汇流畅、划痕测验A、B，汉诺塔、威斯康辛卡片分类改良版进行评定。将37例健康人在年龄、性别、受教育年限与强迫症组匹配后作为正常对照组，在同期做同样的神经心理测验。结果经氯丙咪嗪治疗10周后，强迫症患者大部分神经心理测验指标（包括注意，记忆，执行功能，语言和非语言表达等）都有统计学意义的改善。结论氯丙咪嗪可以改善强迫症患者的认知功能。
Objective To explore the effect of clomipramine on the cognitive function in obsessive --compulsive disorder （OCD）. Methods 37 patients with OCD according to DSM--IV and ICD--10 were tested by the neuropsychological tests before treatment and ten weeks after treatment. The neuro- psychological tests include the knowledge, mathematics, digit symbol, jigsaw puzzle, digit span, logical memory, visual memory, stroop test, verbal fluency, trial making A and B, tower of Hanoi and modi- fied version of Wisconsin card sorting test. 37 healthy persons in control group were paired with patients by age, gender, years of education and tested by the same neuropsychological tests at the same time. Re- suits Most results of neuropsyehological tests have significantly been improved after treatment, inclu- ding memory, attention, execution function, verbal and nonverbal of expression, etc. Conclusions Clo- mipramine can improve the Cognitive function in OCD.
出处
《神经疾病与精神卫生》
2010年第2期153-155,共3页
Journal of Neuroscience and Mental Health
关键词
强迫症
氯丙咪嗪
认知功能
Obsessive--compulsive disorder
Clomipramine
Cognitive function
