摘要
目的探讨垂体肿瘤转化基因(pituitary tumor transforming gene,PTTG)在大肠癌中的表达及其与大肠癌临床病理特征的关系。方法采用免疫组化MaxVision两步法对63例大肠癌组织及距癌灶3 cm以外的癌旁组织、距癌灶10 cm以外的正常组织中PTTG进行检测。结果PTTG在癌组织中表达的阳性率明显高于癌旁和非癌组织(P<0.01、P<0.01);并在不同年龄组(<60岁和≥60岁)、不同组织学分级(高分化和中、低分化)、有或无淋巴结转移及肿瘤不同浸润深度(肌层和浆膜层)病例中表达差异有显著性(P<0.05,P<0.01,P<0.05,P<0.01)。结论PTTG在大肠癌的发生、发展中起重要作用;可以作为临床判断大肠癌生物学行为有用的分子生物学指标。
Purpose To investigate the relationship between the expression of PTTG and clinical pathological characteristics in colorectal carcinoma.Methods PTTG expression was detected in 63 cases of colorectal carcinoma by immunohistochemical method,which included the tumor tissue,adjacent tissues 3 cm far from the carcinoma,and normal tissues 10 cm far from the carcinoma.Results The positive rate of PTTG expression was significantly higher in cancer than that in adjacent tissues and normal tissues（P0.01,P0.01,respectively）.There was a significant difference in the PTTG expression at different age group,different pathological grade,different invasive depth,and whether or not accompanied by lymphatic metastasis（P0.05,P0.01,P0.05,P0.01,respectively）.Conclusion PTTG play an important role in the pathogenesis and development of the colorectal carcinoma,and may be used as a useful marker in clinical evaluation of biological behavior of the tumor.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2010年第2期148-150,共3页
Chinese Journal of Clinical and Experimental Pathology
基金
陕西省卫生厅基金(08D41)
西安医学院科研基金(2006FZ3)
关键词
大肠肿瘤
PTTG
免疫组织化学
colorectal neoplasms
pituitary tumor transforming gene
immunohistochemistry
