摘要
目的评价苦参素葡萄糖(保肝中药)注射液对肿瘤化疗药物所致肝损害的预防作用。方法采用自身对照的方法,83例肿瘤患者每例用同一化疗方案连续进行2个周期化疗。第1周期仅单用化疗,第2周期在化疗同时加用苦参素葡萄糖注射液保肝,观察化疗后肝功能变化。结果保肝组肝功能损害的发生率(10.84%)明显低于单纯化疗组(25.30%),且其肝损害程度明显轻于化疗组(P<0.01)。结论化疗同时加用苦参素葡萄糖注射液保肝治疗可预防化疗药物对肝脏的损害。
Objective To evaluate the effectiveness of kurorinone in preventing hepatic injury caused by chemotherapy durgs. Methods Eighty - three patients with malignant tumor were treated by two cycles of chemotherapy. In the first cycle, they were treated with chemotherapy alone. But we give kurorinone （200 ml everyday）in the next chemotherapy, then observeing the change of liver function. Results The incidence of hepatic injuties wasl0. 84% in the The combination group, but it＇ s 25.30% in the chemotherapy group （P 〈 0. 05 ）. The distribution of hepatic injury degree is also different between two groups （ P 〈 0.01 ）. Conclusion kurorinone is effective in preventing hepatic injury caused by chemotherapy.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2010年第5期336-338,共3页
The Chinese Journal of Clinical Pharmacology
关键词
肿瘤
化疗
苦参素
肝损害
tumor
chemotherapy
kurorinone
hepatic injury
