摘要
整合素αVβ3作为整合素家族中的重要成员,介导了细胞和细胞外基质、细胞和细胞之间的相互黏附,具有调控细胞增殖、分化、细胞形态和迁移等多种功能,在肿瘤血管生成的过程中发挥重要的作用。作为靶向肿瘤的受体,利用核素、核磁共振、超声波和光学等影像技术,结合靶向整合素αVβ3分子成像探针非侵入性的检测整合素αVβ3在肿瘤组织和肿瘤新生血管中的表达,具有潜在的临床应用价值,可用于临床肿瘤诊断和抗肿瘤药物的临床治疗后观察。本文主要针对现有靶向整合素αVβ3的分子探针及其影像技术作一简要综述。
Integrin αVβ3, one of the major members of the integrin family, plays a pivotal role in tumor angiogenesis because it mediates the cell-extracellular matrix and cell to cell adhesion as well as controls cells proliferation, differentiation, cellular modality and motility.Due to restricted high-expressions in tumors, integrin αVβ3, is considered a suitable targeting receptor for tumor diagnosis.In the past decade, several molecular imaging tracers for integrin αVβ3, have been used to noninvasively visualize its expression in tumor tissues and angiogenic blood vessels through the usage of nuclear imaging, nuclear magnetic resonance imaging, ultrasound, and optical imaging.Noninvasive detection of integrin αVβ3, expression can potentially be used for tumor diagnosis and prognosis.The current imaging probes used to target integrin αVβ3, through usage of different technologies are briefly recapitulated in this review.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2010年第4期303-307,共5页
China Oncology
基金
上海市教育重点学科建设项目(No.J50201)
上海市高校选拔培养优秀青年教师科研基金项目
